A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells.

A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells. Chem Commun (Camb). 2018 Apr 03;: Authors: Hu Z, Yang L, Ning W, Tang C, Meng Q, Zheng J, Dong C, Zhou HB Abstract Estrogen receptor β (ERβ) has recently been identified as a pharmaceutical target in hormone replacement therapy for breast cancers. However, the biological function of ERβ in disease progression remains unclear. A highly ERβ-selective fluorescent probe (FPNM) was discovered exhibiting nanomolar affinity for ERβ with an ERβ/ERα selectivity as high as 80, which allowed specific labeling of intracellular ERβ. Moreover, distinct ERβ dynamics in various cellular bio-settings such as prostate cancer (DU-145) or triple-negative breast cancer (MDA-MB-231) cells were directly observed for the first time via FPNM staining. PMID: 29610818 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research

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ConclusionsSince the leading cause of death in patients with type 2 diabetes is cancer in Japan, clinicians should be aware of epidemiological data regarding cancer besides diabetic complications.
Source: Diabetology International - Category: Endocrinology Source Type: research
Conclusions Walking pace is associated with lower risk of a wide range of important health conditions, independently of overall time spent walking.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: EPIDEMIOLOGY Source Type: research
ConclusionPIM use was significantly associated with greater healthcare utilization and higher healthcare costs in this population. Future research should be undertaken to obtain additional evidence that can aid in the optimization of integrated interdisciplinary programs to facilitate effective management of care for older patients with cancer and other co-morbid medical problems.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Diagnosis with a variety of health conditions appears to prompt drinking cessation in older adults. This article is protected by copyright. All rights reserved. PMID: 30758044 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research
Ma Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to regulate alternative pre-mRNA splicing and gene expression. However, Malat1 knockout mice develop and grow normally, and do not show alterations in alternative splicing. While MALAT1 was originally described as a prognostic marker of lung cancer metastasis, emerging evidence has linked this lncRNA to other cancers, such as breast cancer, prostate cancer, pancreatic c...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Each year, more than 1.7 million people in the United States hear three dreaded words: You have cancer. As common as cancer is, no one expects cancer to happen to them. We understand, as patients and as caregivers, how frightening a cancer diagnosis can be: how it can upend your life, leaving you feeling like you’re barely treading water. And we know that making tough decisions when your life depends on it is not easy. From our research at Harvard Business School of how people navigate their cancer treatment (and what they wish they had known sooner), we have developed four steps that all people with cancer can take ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer Source Type: news
Much has been researched and written about the promise of PET/MRI. While the...Read more on AuntMinnie.comRelated Reading: Ga-68 PSMA-11 PET/MRI benefits prostate cancer patients TOF PET/MRI makes dose reduction viable for breast cancer How effective is PET/MRI for rectal cancer? PET/MRI with ferumoxytol MR contrast performs well for pediatric patients Cardiac FDG-PET/MRI's role in Anderson-Fabry disease
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Working with radiomics data on multiparametric MRI (mpMRI) scans, an artificial...Read more on AuntMinnie.comRelated Reading: Advanced imaging offers insight into targeted therapies AI can predict breast cancer molecular subtypes on MRI AI can differentiate glioblastoma, brain metastasis CT radiomics improves management of bile duct cancer Faster MRI protocol avoids unneeded prostate biopsies
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ABSTRACTTumor doubling time can significantly affect the outcome of anticancer therapy, but it is very challenging to determine. Here, we present a statistical approach that extracts doubling times from progression-free survival (PFS) plots, which inherently contains information regarding the growth of solid tumors. Twelve cancers were investigated and multiple PFS plots were evaluated for each type. The PFS plot showing fastest tumor growth was deemed to best represent the inherent growth kinetics of the solid tumor, and selected for further analysis. The exponential tumor growth rates were extracted from each PFS plot, a...
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research
errez-Aguilar M, García-Arrazola R Abstract In the present work, cell lines of different origin were exposed to BPA levels from food intake reported elsewhere. Specifically, we used an in vitro assay to determine cytotoxicity of BPA in three cell lines: MCF7 (breast cancer), PC3 (prostate cancer) and 3T3-L1 (mouse fibroblast). Cytotoxic effects were observed at concentrations higher than 50 μg/mL which is above the involuntary exposure level of BPA described before in fresh, canned and frozen foods and beverages. Furthermore, medial inhibitory concentrations (IC50) of 85.17 μg/mL and 88.48&n...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
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