Impact of polysomy 17 on HER2 testing of invasive breast cancer patients.

CONCLUSIONS: Polysomy 17 is a crucial cause of equivocal HER2 testing results by FISH, depending on which criterion (ratio vs. absolute number) is used for interpretation. Polysomy 17 cannot be an independent predictive factor for HER2 gene amplification or protein overexpression.
PMID: 24427336 [PubMed - indexed for MEDLINE]

Source: Clinical Breast Cancer - September 8, 2014 Category: Cancer & Oncology Authors: Liu Y, Ma L, Liu D, Yang Z, Yang C, Hu Z, Chen W, Yang Z, Chen S, Zhang Z Tags: Int J Clin Exp Pathol Source Type: research