Cerebral white matter disease and functional decline in older adults from the Northern Manhattan Study: A longitudinal cohort study

ConclusionsIn this large population-based study, greater whole brain WMHV was associated with steeper annual decline in functional status over the long term, independently of risk factors, vascular events, and baseline functional status. Subclinical brain ischemic changes may be an independent marker of long-term functional decline.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research