Genomic complexity in pediatric synovial sarcomas (Synobio study): the European pediatric soft tissue sarcoma group (EpSSG) experience

This study analyzes 61 pediatric/adolescent/young adults (<25 years) with localized synovial sarcoma prospectively enrolled in the European EpSSG‐NRSTS05 protocol to demonstrate that somatic genomic index (GI) analyzed using comparative genomic hybridization had a high prognostic value in pediatric synovial sarcoma as an independent prognostic factors. It demonstrates that patients with tumor harboring high GI had worse five‐year event‐free and metastatic‐free survivals comparing to ones with no genomic instability, and that therefore GI could be used to stratify more accurately patients in the future.

Source: Cancer Medicine - March 13, 2018 Category: Cancer & Oncology Authors: Daniel Orbach, V éronique Mosseri, Daniel Pissaloux, Gaelle Pierron, Bernadette Brennan, Andrea Ferrari, Frederic Chibon, Gianni Bisogno, Gian Luca De Salvo, Camille Chakiba, Nadège Corradini, Véronique Minard‐Colin, Anna Kelsey, Dominique Ranchère� Tags: Original Research Source Type: research