Cardiovascular Morbidity and Mortality in Thyroid Cancer Cardiovascular Morbidity and Mortality in Thyroid Cancer

What do we know about the cardiovascular risks of thyroid hormone suppression therapy for thyroid cancer?Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

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Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0629-9223 Purpose Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. Methods We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. On the basis of availability of pathological specimen of thyroid tissues,...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Authors: Hepp Z, Lage MJ, Espaillat R, Gossain VV Abstract OBJECTIVE: To evaluate outcomes associated with adherence to levothyroxine (LT4) in the US adult hypothyroidism population. METHODS: We used data from Truven's MarketScan databases from July 1, 2011 through December 31, 2015. Patients aged 18 or older were diagnosed with hypothyroidism (confirmed at least twice) and prescribed LT4. Patients were excluded if they did not have continuous insurance coverage or if they received a diagnosis of thyroid cancer or pregnancy during the study period. Multivariable analyses on a matched cohort of adherent and non-...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Authors: Cho YY, Kang MJ, Kim SK, Jung J, Hahm JR, Kim TH, Nam JY, Lee BW, Lee YH, Chung JH, Song SO, Kim SW Abstract BACKGROUND: Metformin, the most widely used drug for type 2 diabetes has recently attracted attention with regard to its anti-tumor activity. However, clinical studies have yielded conflicting results regarding the association between metformin and thyroid cancer development despite its anti-tumor effect in preclinical studies. METHODS: This was a retrospective cohort study using the Korean National Health Insurance claims database. Matched populations of 128,453 metformin users and 128,453 non-...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
This study was registered with ClinicalTrials.gov, number NCT00435851. Findings 726 patients (97% of the 752 patients originally randomised) were followed up. At a median follow-up since randomisation of 5·4 years (range 0·5–9·2), 715 (98%) had no evidence of disease. The other 11 had either structural disease (n=4), raised serum thyroglobulin concentration (n=5), or indeterminate findings on neck ultrasonography (n=2). At ablation, six of these patients had received 1·1 GBq radioactive iodine (five after rhTSH and one after withdrawal) and five had received 3·7 GBq (two after rhTSH...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 26 May 2018 Source:The Lancet Diabetes & Endocrinology Author(s): Furio Pacini
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Physicians at hospital in Japan detail how active surveillance of low-risk papillary thyroid microcarcinomas has evolved, hoping to encourage other countries that have been slower to adopt the approach.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Conclusion: Our preliminary studies showed the relation between BAT thermogenesis and sleep, suggesting its implication for health. This study, which evaluated the impact of SR on BAT and its role on RecS, will provide information on the function of BAT that will be relevant for individuals with sleep disorders and those at risk of obesity and its associated chronic metabolic conditions; namely type 2 diabetes, hypertension, and cardiovascular disease. The outcome of this study may provide further insight for treatment related to sleep disorders and obesity by providing information on the physiological role of BAT in sleep...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
1341Objectives: Salivary gland damage is a common adverse effect of high dose radioiodine therapy for thyroid cancer. So far, less is known about possible salivary gland damages following low dose I-131 ablation (RIA) with rhTSH stimulation. The aim of this study was to investigate whether salivary gland damages is induced by low dose RIA for thyroid cancer. Methods: 59 patients with post-surgical papillary thyroid cancer (M/F 15/34, age:27-75yrs.), who were to undergo first time RIA with 30mCi of I-131, were enrolled. None of the patients had previous history of salivary gland disorders, diabetes, or collagen tissue disea...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
If you have mesothelioma and you’ve already received standard-of-care therapies, you may be considering an immunotherapy clinical trial. If you’re considering this option, a free immunotherapy teleconference is a great place to learn more. CancerCare recently hosted two one-hour education workshops featuring panels of immunotherapy experts. Part I of the teleconference presented an overview of immunotherapy. Part II of the teleconference, which is available online for free, focused exclusively on immunotherapy side effects. Understanding these issues and the role each patient plays in managing their own side ef...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Authors: Sárközy M, Kahán Z, Csont T Abstract Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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