‘Lipid Raft Aging’ in the Human Frontal Cortex During Non-Pathological Aging: Gender Influences and Potential Implications in Alzheimer’s Disease

Lipid rafts are highly dynamic membrane domains featured by distinctive biochemical composition and physicochemical properties compared to the surrounding plasma membrane. These microstructures are associated not only with cellular signalling and communication in normal nerve cells but also with pathological processing of amyloid precursor protein in Alzheimer ’s disease. Using lipid rafts isolated from human frontal cortex in non-demented subjects aging 24-85 years, we demonstrate here that lipid structure of lipid rafts undergo significant alterations of specific lipid classes and phospholipid-bound fatty acids as brain cortex correlating with aging.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research