rAsp f3 and rAsp f4 are associated with bronchiectasis in allergic fungal airways disease

Allergy to thermotolerant filamentous fungi, particularly Aspergillus fumigatus, is closely associated with fixed airflow obstruction, bronchiectasis, and other radiologically defined abnormalities, such as mucus plugging.1 However, not all asthma patients who are immunoglobulin E (IgE) sensitized to A fumigatus develop these complications. To identify markers of poor outcomes in fungal allergy with asthma (and cystic fibrosis), the term allergic bronchopulmonary aspergillosis (ABPA) was coined.

Source: Annals of Allergy, Asthma and Immunology - December 7, 2017 Category: Allergy & Immunology Authors: Kerry Woolnough, Michelle Craner, Catherine H. Pashley, Andrew J. Wardlaw Source Type: research