Cord Blood Unit Dominance Analysis and Effect of the Winning Unit on Outcomes after Double Unit Umbilical Cord Blood Transplantation in Adults with Acute Leukaemia: a Retrospective Study on Behalf of Eurocord, the Cord Blood Committee of Cellular Therapy, Immunobiology Working Party and the Acute Leukaemia Working Party of the EBMT

This study aimed to evaluate which W-CBU factors can predict unit dominance and how they influence DUCBT outcomes in patients with acute leukaemia• No W-CBU factors were associated with unit dominance• DUCBT outcomes were negatively influenced by higher degree of HLA mismatch between W-CBU a nd recipient• Selecting both units based on lower degree of HLA mismatch along with other standard selection criteria is indicated

Source: Biology of Blood and Marrow Transplantation - February 22, 2018 Category: Hematology Authors: Karina Tozatto-Maio, Federica Giannotti, Myriam Labopin, Annalisa Ruggeri, Fernanda Volt, Annalisa Paviglianiti, Chantal Kenzey, Hiromi Hayashi, Jan Cornelissen, Mauricette Michallet, Dimitrios Karakasis, Eric Deconinck, Pierre-Simon Rohrlich, Regis Peffa Source Type: research