Synthesis, biological evaluation and docking study of some novel isoxazole clubbed 1,3,4-oxadiazoles derivatives

AbstractA novel series of isoxazole clubbed 1,3,4-oxadiazole derivatives have been synthesized by reaction of 5-(3-fluoro-4-methoxyphenyl) isoxazole-3-carbohydrazide with different substituted benzoic/pyridinyl/indolyl acids in phosphorous oxychloride, characterized by IR,1H NMR,13C NMR, MS analytical data and evaluated for their antimicrobial as well as antitubercular activity. Antibacterial activity of compounds5e,5g,5h,5j and5l were found to be good againstE. coli, P. aeruginosa, S. aureus andS. pyogenes as compared to standard Ampicillin. Compound5b and5i were found to be active antitubercular agents againstM. tuberculosis H37Rv. Antibacterial and antitubercular activity was supported by molecular docking to gain insights of the mode of inhibition of MurD ligase enzyme.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research