Metabolism, Metabolomics, and Inflammation in Post-Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is defined by classic psychological manifestations, although among the characteristics are significantly increased rate of serious somatic comorbidities, such as cardiovascular disease, immune dysfunction and metabolic syndrome. In this review, we assess the evidence for disturbances which may contribute to somatic pathology in inflammation, metabolic syndrome, and circulating metabolites (implicating mitochondrial dysfunction) in individuals with PTSD and in animal models simulating features of PTSD.

Source: Biological Psychiatry - February 21, 2018 Category: Psychiatry Authors: Synthia H. Mellon, Aarti Gautam, Rasha Hammamieh, Marti Jett, Owen M. Wolkowitz Tags: Review Source Type: research