Cloning and expression of porcine β1,4 N‐acetylgalactosaminyl transferase encoding a new xenoreactive antigen

ConclusionThe functional isolation of the porcine B4GALNT2 gene from a PAEC expression library, the pattern of B4GALNT2 gene expression and its sensitization of HEK‐B4T cells to antibody binding and complement mediated lysis indicates that the enzymatic activity of porcine B4GALNT2 produces a new immunogenic non‐Gal glycan which contributes in part to the non‐Gal immune response detected after pig‐to‐baboon cardiac xenotransplantation.

Source: Xenotransplantation - September 1, 2014 Category: Transplant Surgery Authors: Guerard W. Byrne, Zeji Du, Paul Stalboerger, Heide Kogelberg, Christopher G. A. McGregor Tags: Original Article Source Type: research