Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion –negative rhabdomyosarcoma: A report from the Children's Oncology Group

CONCLUSIONSInterestingly, Hh and mTOR gene mutations were previously associated with rhabdomyomas, which are also known to preferentially arise at head/neck and genitourinary sites. Findings from this study further support the idea that PF–, highly differentiated RMS tumors and rhabdomyomas may represent a continuous spectrum of tumors. Cancer 2018. © 2018 American Cancer Society.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fcncr.31286

Source: Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Lisa A. Teot, Michaela Schneider, Aaron R. Thorner, Jing Tian, Yueh ‐Yun Chi, Matthew Ducar, Ling Lin, Marcin Wlodarski, Holcombe E. Grier, Christopher D. M. Fletcher, Paul van Hummelen, Stephen X. Skapek, Douglas S. Hawkins, Amy J. Wagers, Carlos Rodri Tags: Original Article Source Type: research