Myt1l induced direct reprogramming of pericytes into cholinergic neurons.

CONCLUSIONS: Our findings provided proof of the principle that cholinergic neurons could be produced from HBVPs by reprogramming factor-mediated fate instruction. Myt1l was a critical mediator of induced neuron cell reprogramming. HBVPs represent another excellent alternative cell resource for cell-based therapy to treat neurodegenerative disease.
PMID: 29453933 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - February 17, 2018 Category: Neuroscience Authors: Liang XG, Tan C, Wang CK, Tao RR, Huang YJ, Ma KF, Fukunaga K, Huang MZ, Han F Tags: CNS Neurosci Ther Source Type: research