Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice

Hepatic ischemia reperfusion (I/R) injury is a major complication of severe hypotension followed by fluid resuscitation, liver resection, and liver transplantation [1]. Hepatic I/R injury followed by hepatic tissue repair significantly affects post-operative liver function and survival, since insufficient liver restoration is associated with increased morbidity and mortality [2,3]. Thus, the balance between hepatocyte death and subsequent liver repair and regeneration determines the prognosis of patients with hepatic I/R injury.

Source: Journal of Hepatology - February 17, 2018 Category: Gastroenterology Authors: Nobuyuki Nishizawa, Yoshiya Ito, Koji Eshima, Hirotoki Ohkubo, Ken Kojo, Tomoyoshi Inoue, Joan Raouf, Per-Johan Jakobsson, Satoshi Uematsu, Shizuo Akira, Shuh Narumiya, Masahiko Watanabe, Masataka Majima Source Type: research