Potential pharmaceutic effect of Shilajit (mumie) on experimental osteoarthritis in rat

AbstractOsteoarthritis (OA) is a worldwide joint disease with clinically loss of motion and pain in human. The conventional treatments are associated with essential side effects. In folk medicine, Shilajit is applied for treatment of arthritis and bone fractures. The present study evaluated effect of Shilajit on the osteoarthritis in rat model. Thirty-six adult male rats were randomly divided into two groups including OA and treated with Shilajit groups. OA was induced by injection of monosodium iodoacetate in the articular space of femorotibial joint. Aqueous extract of Shilajit was given to the treatment group by gavage as daily during experimental course until 21  days. The joint samples were investigated 7, 14, and 21 days post induction. The main macroscopic changes in the affected joints were swelling and congestion at early stages. Histopathologic study showed surface irregularity, erosion and fissures, necrotic chondrocytes, depletion of toluidine blu e staining, and lysis of subchondral bone in both OA and Shilajit groups after 7 and 14 days. Synovium revealed synovial cells hyperplasia and inflammatory cells infiltration. Moderate to advanced OA was seen in both groups without significant difference. After 21 days, histopathologic scores of d estructive damages and synovitis were reduced in the Shilajit group and showed significant difference in compare to OA group. The present study shows that aqueous extract of Shilajit decreased cartilage dege...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

Related Links:

Publication date: Available online 19 August 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Xiu-feng GU, Fei WANG, Yan-yan ZHANGAbstractObjectiveTo compare the therapeutic effect difference among dog-day moxibustion on herbs, ordinary moxibution and routine western medication in treating knee-joint osteoarthritis of yang deficiency and congealing cold type.MethodsA total of 90 patients with knee-joint osteoarthritis of yang deficiency and congealing cold type were divided into dog-day moxibustion group, ordinary moxibution group and western medication group according to the registration order, and there w...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
ConclusionPain improved considerably in both arms over 60 months. While ITT analysis revealed no statistically significant differences in TKR use, greater TKR utilization in those receiving APM merits further study.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Authors: Safran MR, Bedi A, Byrd JWT, Guanche CA, Ilizaliturri V, Lynch TS, Martin HD, Matsuda DK, McCarthy JC, Philippon MJ, Sampson TG, Suarez-Ahedo C Abstract Hip arthroscopy is one of the most rapidly growing areas in orthopaedic surgery because of increased awareness of nonarthritic hip pathologies, advanced imaging modalities, and advanced techniques to reproducibly manage nonarthritic hip pathologies within a deep soft-tissue envelope and a constrained joint. In addition, more academic medical centers are providing residents with education on hip arthroscopy, and many hip preservation fellowships and courses...
Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
CONCLUSION: Patients with WD who develop ALF with an NWIS> 11 may survive after treatment with Zn and chelators, without liver transplantation, when they present with mild hyperbilirubinemia and stage ≤ II hepatic encephalopathy. Osteoarthritis symptoms may improve with long-term Zn and chelator therapy without correlation of liver function in WD. PMID: 31388402 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Pain relievers such as ibuprofen and naproxen may account for higher rates of heart disease and stroke in those with osteoarthritis.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Heart Arthritis Osteoarthritis Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Ibuprofen (Drug) Aleve (Drug) Source Type: news
In conclusion, with study of the frailty syndrome still in its infancy, frailty analysis remains a major challenge. It is a challenge that needs to be overcome in order to shed light on the multiple mechanisms involved in the pathogenesis of this syndrome. Although several mechanisms contribute to frailty, immune system alteration seems to play a central role: this syndrome is characterized by increased levels of pro-inflammatory markers and the resulting pro-inflammatory status can have negative effects on various organs. Future studies should aim to better clarify the immune system alteration in frailty, and seek to esta...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsMore than half of Medicaid beneficiaries receiving an opioid for pain management do so for orthopedic- and dental-related reasons, with emergency department providers more likely to prescribe opioids. Modifications to the guidelines addressing temporary acute pain management practices with opioids would be likely to benefit emergency department providers the most.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
In this study, UBX0101 was well-tolerated. Improvement in several clinical outcomes, including pain and function, as well as modulation of certain senescence-associated secretory phenotype (SASP) factors and disease-related biomarkers was observed after a single dose of UBX0101. UNITY plans to initiate a Phase 2 study of UBX0101 in patients with painful, moderate-to-severe OA of the knee. The study is expected to enroll approximately 180 patients with initiation expected in the fourth quarter of 2019 and initial 12-week results expected in the second half of 2020. This will be a randomized, double-blind, placebo-con...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conditions:   Hip Dysplasia;   Hip Pain Chronic;   Hip Osteoarthritis;   Hip Arthritis;   Psychosocial Problem Interventions:   Device: Cell Phone Based Cognitive Based Therapy (Pacifica App);   Other: Control Sponsor:   Michael C Willey Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
DISCUSSION: Given the good clinical outcomes after both TSA and RSA, there may be an increased role for RSA in this elderly cohort to provide effective treatment of glenohumeral osteoarthritis. LEVEL OF EVIDENCE: Level III, retrospective comparative study. PMID: 31356423 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
More News: Arthritis | Orthopaedics | Osteoarthritis | Pain | Pathology | Rheumatology | Study