Effects of recombinant human parathyroid hormone (1-34)on cell proliferation, chemokine expression and the Hedgehog pathway in keratinocytes.

In conclusion, these data suggested that rhPTH (1‑34) inhibited cell proliferation, and the secretion and expression of CXCL11 in HaCaTs. rhPTH (1‑34) also altered the expression of associated genes in the Hedgehog pathway. Therefore, rhPTH (1‑34) can be considered as a novel therapeutic agent for the treatment of psoriasis. PMID: 29436626 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research