NF- κB in pancreatic cancer: Its Key Role in Chemoresistance

Pancreatic cancer is considered a lethal disease with a high mortality and an extremely low five-year survival rate. Chemotherapy plays a pivotal role in pancreatic cancer treatment both in an adjuvant setting after complete resection and in the case of unresectable metastatic disease. However, none of the available combination chemotherapy regimens has resulted in satisfactory survival outcomes. Recent studies have revealed that both constitutive and induced activation of nuclear factor kappa B (NF- κB) in pancreatic cancer cells are closely associated with cell proliferation, invasion, anti-apoptosis, inflammation, angiogenesis and chemotherapeutic resistance.

Source: Cancer Letters - February 9, 2018 Category: Cancer & Oncology Authors: Quanxiao Li, Gang Yang, Mengyu Feng, Suli Zheng, Zhe Cao, Jiangdong Qiu, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang, Yupei Zhao Tags: Mini-review Source Type: research