Systemic lupus erythematosus: disease activity may influence the release of endothelial microparticles?

To evaluate blood-borne endothelial microparticles (EMPs) in women with SLE and correlated these to disease activity as defined by the SLEDAI-2K score. The study takes cross-sectional design. A total of 90 age-matched women were recruited including: G1 (healthy volunteers, n = 30), G2 (women with SLE and low disease activity (SLEDAI-2K score ≤4; n = 30) and G3 (women with SLE and moderate/high disease activity (SLEDAI-2K score>4; n = 30). Blood was collected in 3.2% sodium citrate. Subsequently, the microparticles were purified by ultracentrifugation and labeled with anti-CD51/61 and anti-Annexin-V antibodies. Quantification and phenotyping were performed using flow cytometry. The number of EMPs was significantly higher in SLE patients compared with controls (P = 0.0178). When SLE patients were stratified according to disease activity, the number of EMPs was significantly increased in women with moderate-to-high disease activity compared with controls (P = 0.0074). We observed a correlation between the number of EMPs and age (r = −0.34; P = 0.0123) and between the number of EMPs and SLEDAI-2K score (r = 0.30; P = 0.04). Our results suggest that the SLE causes increased EMPs release, especially in patients with SLEDAI-2K score greater than 4. Although measurement of the EMPs could be useful in distinguishing patients with SLE from health controls, they have limited value in differentiating between SLE subtypes.
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: Original Articles Source Type: research

Related Links:

ConclusionPatients with recurrent aphthous stomatitis were associated with increased risk of specific comorbidities. Physicians should screen for these comorbidities for early detection and treatment.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Authors: Chen W, Li FF, Li C, Sui JK, Meng QF, Li XL, Li H, Li CH, Li YB Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by fatigue and muscle weakness. Artemisinin and its derivatives were reported to be experimentally used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and experimental allergic encephalomyelitis (EAE). Here, we tested the effects of artemisinin on experimental autoimmune myasthenia gravis (EAMG). Our data confirmed that artemisinin markedly ameliorated the symptoms of EAMG rats. There was a decreased level of tumor necrosis factor-α (TNF-&alp...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
(MedPage Today) -- What are outcomes for patients with both conditions?
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
This study was performed to demonstrate the clinical and histological features of GR and LMDF and to establish their relationship to tuberculous etiology by molecular technique. All the cases of GR (n = 20) and LMDF (n = 10) diagnosed on skin biopsy over the past 6 years were reviewed along with their clinical detail. Polymerase chain reaction (PCR) was performed using primers specific for Mycobacterium tuberculosis. The mean age of patients with GR was 45 years 10 months (range 18–75 years) as compared to 33 years 5 months (range 18–57 years) in patients with LMDF. The GR cases comprised 13 men and 7 women pat...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
(Northwell Health) Results shared at ACR/ARHP annual meeting highlight non-invasive therapy reduces pain and fatigue associated with lupus.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Natural News) It’s believed that inadequate vitamin D levels can increase one’s susceptibility to disease, and vice versa. The effects of vitamin D on disease are such that many experts have recommended supplementing this vitamin to people suffering from autoimmune disease such as systemic lupus erythematosus (SLE). Curcumin has been endorsed for this purpose as...
Source: - Category: Consumer Health News Source Type: news
Authors: Yagita M, Hata S, Miyata H, Kakita H, Tsukamoto T, Muso E, Fujita M Abstract Systemic lupus erythematosus may be associated with various types of malignancy. However, systemic lupus erythematosus occurring with ovarian cancer seems rare, and reliable therapeutic approaches for such cases have yet to be identified. We herein report a case of systemic lupus erythematosus with ovarian cancer that was successfully treated with corticosteroid, plasmapheresis and chemotherapy. This case may provide new insights into treatment approaches for systemic lupus erythematosus with ovarian cancer. PMID: 30333422 [Pu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We present the case report of a 32-year female whose complaints was abdominal pain for one  week and no history of previous foetal loss, who responded well to warfarin and has not developed systemic lupus erythematous even after follow up. Characteristic of this patient is the appearance of auto antibodies against Golgi bodies. Although antinuclear antibodies are seen in patients of rheu matic disease like systemic lupus erythematous, its presence in individuals with unusual presentation of antiphospholipid syndrome may facilitate in diagnosis.
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research
ConclusionConsidering that TLR3 signaling is implicated in LN pathogenesis, our results suggest that chloroquine exert postulated renoprotective effects by inhibiting PAI-1 expression.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Lupus nephritis (LN) is a frequent severe complication of Systemic Lupus Erythematosus (SLE), especially in patients of non-Caucasian ethnicity. Induction treatment for LN consists in the combination of steroi...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Case report Source Type: research
More News: Hematology | Lupus | Sodium | Study | Women