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New study explains how your brain helps you learn new skills

(Gladstone Institutes) Researchers from the Gladstone Institutes uncovered how a special type of neuron improves the efficiency of procedural learning. They initially wanted to show how the specialized brain cells, called fast-spiking interneurons, cause movement disorders, such as Tourette's syndrome, dystonia, and dyskinesia. As it turns out, that isn't the case. But their work led them to an even greater discovery.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Condition:   Parkinson Disease Interventions:   Drug: IRL790;   Drug: Placebo Sponsor:   Integrative Research Laboratories AB Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Tourette Syndrome Interventions:   Drug: Valbenazine;   Drug: Placebo oral capsule Sponsor:   Neurocrine Biosciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 18 May 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Melissa M. Conti, Nicole Chambers, Christopher Bishop Traditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered antagonistic and imbalances or aberrant signaling between these neurotransmitter systems could be detrimental to basal ganglia activity and pursuant motor function, such as in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). Herein, we discuss the involvement of cholinergic interneurons (ChIs) in striatally-mediated movement in a healthy, parkinsonian, and dyski...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Insightec said this week it submitted an application for pre-market approval to the Japanese Pharmaceuticals and Medical Devices Agency seeking an indication for its Exablate Neuro to treat advanced Parkinson’s Disease in patients suffering from mobility, rigidity or dyskinesia. The Israel-based company’s Exablate Neuro device uses high-intensity, focused ultrasound to thermally ablate targeted tissue, guided by continuous magnetic resonance imaging; the procedure can be performed non-invasively through an intact skull. “Insightec is committed to supporting research that extends the applica...
Source: Mass Device - Category: Medical Devices Authors: Tags: Neurological Regulatory/Compliance Ultrasound INSIGHTEC Source Type: news
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
ConclusionsADS-5102 can be administered once-daily qhs to achieve high amantadine plasma concentrations in the morning and throughout the day, when symptoms of dyskinesia occur.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
AbstractA movement disorder emergency has been defined by Fahn and Frucht as “any neurological disorder evolving acutely or subacutely, in which the clinical presentation is dominated by a primary movement disorder, and in which failure to accurately diagnose and manage the patient may result in significant morbidity or even mortality.” In this review, we discuss the mos t common situations in which hyperkinetic movement disorders, including chorea, ballism, dystonia, myoclonus, tics, as well as psychogenic disorders, can present as emergencies. Some acute hyperkinetic issues that can complicate Parkinson&rsquo...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
New treatment for Tourette's Tics are common and may present to both paediatric and child psychiatry clinics. For most, reassurance and advice are all that is needed, but for a few they can become seriously disabling and may progress to Tourette's syndrome. Treatment with antipsychotic drugs such as Haloperidol is effective, but can severe side-effects such as sedation, dystonia and tardive dyskinesia. Newer ‘atypical’ antipsychotic drugs are being used increasingly in schizophrenia as they appear to be better tolerated. One such is Aripiprazole: researchers from Jiangsu, China set out to review the literature ...
Source: Archives of Disease in Childhood - Category: Pediatrics Tags: Miscellanea Source Type: research
Authors: di Biase L, Munhoz RP Abstract INTRODUCTION: Deep brain stimulation effectiveness is well recognized for different movement disorders including Parkinson's disease, dystonia and essential tremor, however several other diseases in this field may benefit from the technique although experience is sparse and evidences of benefit and risks are not established. AREAS COVERED: In this review, we explored available evidence for effectiveness and safety of DBS in selected hyperkinetic movement disorders, including tardive dyskinesia, Huntington's disease, neuroacanthocytosis, myoclonus-dystonia, Tourette syndro...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Conclusions: AEs following pvGPi DBS in refractory TS were mostly related to stimulation or hardware, but did not limit therapy. Controlled studies are warranted.Disclosure: Dr. Niemann has nothing to disclose. Dr. Strutt has received personal compensation for activities with Psychology Software Tools as a consultant. Dr. Viswanathan has nothing to disclose. Dr. Jimenez Shahed has received personal compensation for activities with Teva as a consultant. Dr. Jimenez Shahed has received research support from Avid Radiopharmaceutical, Inc., Acadia Pharmaceuticals, US World Meds, and Biotie.
Source: Neurology - Category: Neurology Authors: Tags: Movement Disorders: Tics, Tourette ' s Syndrome, and Other Source Type: research
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