NIH inks $5m partnership with PathMaker Neurosystems for MyoRegulator spasticity device

PathMaker Neurosystems said today it signed a $5 million cooperative partnership deal with the National Institutes of Health to support continued development of its MyoRegulator neurostimulation system designed to treat spasticity secondary to stroke. The MyoRegulator device, based on PathMaker’s DoubleStim technology, is designed to provide simultaneous, non-invasive stimulation at spinal and peripheral locations, the Boston and Paris-based company said. The money comes as part of a four-year grant awarded through the CREATE Devices program which also provides a partnership with the NIH’s National Institute of Neurological Disorders and Stroke, PathMaker said. “We are truly honored and delighted to receive this support from NINDS to advance our breakthrough non-invasive neuromodulation technology that can benefit many patients in desperate need of treatment options. This collaborative partnership and funding will support product engineering, multi-center U.S. pivotal trials and regulatory submission for MyoRegulator,” prez &CEO Dr. Nader Yaghoubi said in a press release. “The CREATE Devices program encourages the pursuit of translational and clinical studies for innovative therapeutic devices to treat neurological disorders,” NINDS program director Nick Langhals said in a prepared statement. Last February, PathMaker Neurosystems said that it won a grant from BpiFrance to support its MyoRegulator neurostim device. The pos...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Neuromodulation/Neurostimulation PathMaker Neurosystems Inc. Source Type: news

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Publication date: Available online 18 August 2018Source: Clinica Chimica ActaAuthor(s): Huijun Chen, Xiaoqian Luan, Kai Zhao, Huihua Qiu, Yuntao Liu, Xinjie Tu, Wenjie Tang, Jincai HeAbstractsBackgroundPost-stroke depression (PSD) is the most common complication occurring among stroke survivors. It has been shown that increased neutrophil-to-lymphocyte ratio (NLR) is associated with depression. We explored the relationship between NLR and PSD.MethodsIn total, 299 ischemic stroke patients were consecutively enrolled in the study and received 1 month follow-up. The 17-Hamilton Rating Scale was used to measure depressive sy...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
(MedPage Today) -- This week's topics include vaccination in pregnant women and ASD; treating stroke outside the window; smoking, mortality, and weight gain; and five risk factors for death in type 2 diabetes.
Source: MedPage Today Nephrology - Category: Urology & Nephrology Source Type: news
Conclusions: The results of this study provide an evidence that antigravity positions can be used as a centrally presented facilitator of elbow extension. Additionally, task specific training was effective in improving upper extremity function and elbow extension range of motion. PMID: 30112205 [PubMed]
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
CONCLUSIONS: The findings of this study reveal the possibility of cognitive recovery after brain damage. No recovery differences were found for vascular and traumatic lesions. PMID: 30118616 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
ConclusionsEmbolism is a major problem encountered by patients under LVAD support while waiting for an HT. Thrombectomy for AIS associated with LVAD support is a useful and safe treatment modality. It is possible to maintain a reasonable mRS score in patients who are not completely independent.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Authors: Pickham D, Valdez A, Demeestere J, Lemmens R, Diaz L, Hopper S, de la Cuesta K, Rackover F, Miller K, Lansberg M Abstract BACKGROUND: Use of prehospital stroke scales may enhance stroke detection and improve treatment rates and delays. Current scales, however, may lack detection accuracy. As such, we examined if coordination and diplopia (Balance and Eyes) assessments increase the accuracy of the Face-Arms-Speech-Time (FAST) scale in a multi-site prospective study of emergency response activations for presumed stroke. METHODS: This was a prospective study of emergency response activations for presumed ...
Source: Prehospital Emergency Care - Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
CONCLUSIONS: PMES was a safe, effective, and low-cost therapy to alleviate HRV and could significantly reduce mortality in the early recovery phase after acute ischemic stroke. PMID: 30111262 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
ConclusionNLR predicts all-cause mortality, MACE, and HF hospitalization 1-year post-TAVR. NLR with TAVR risk score improved predictability for MACE. Further studies for prognostication utilizing NLR are warranted.
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 17 August 2018Source: Canadian Journal of CardiologyAuthor(s): Seung Yong Shin, Gregory Y.H. LipAbstractAtrial fibrillation (AF) is a common and progressive heart rhythm disorder that causes structural, functional and electrical remodelling of the heart. Although we do not fully understand AF yet, this arrhythmia is one clinical feature of a syndrome that is represented by irregularly irregular atrial rhythm accompanied by progressive atrial structural and functional remodelling. Although ischemic stroke, most feared complication of AF, can be prevented by anticoagulation, asymptomatic or...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 17 August 2018Source: Neuroscience LettersAuthor(s): Selva Baltan, Chinthasagar Bastian, John Quinn, Danielle Aquila, Andrew McCray, Sylvain BrunetAbstractStrokes occur predominantly in the elderly and white matter (WM) is injured in most strokes, contributing to the disability associated with clinical deficits. Casein kinase 2 (CK2) is expressed in neuronal cells and was reported to be neuroprotective during cerebral ischemia. Recently, we reported that CK2 is abundantly expressed by glial cells and myelin. However, in contrast to its role in cerebral (gray matter) ischemia, CK2 activati...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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