[Essential tremor: state of the art].

[Essential tremor: state of the art].
Nervenarzt. 2018 Feb 05;:
Authors: Deuschl G, Berg D
Abstract
Essential tremor (ET) is currently classified as a syndrome rather than a unique disease, primarily involving monosymptomatic action tremor in both hands. Different etiologies are presumed to underlie this condition. Currently only a few monogenetic conditions are known to present with this syndrome. If accompanied by additional symptoms that do not in themselves constitute a new syndrome, such as abnormal tandem gait or postures, the syndrome should be diagnosed as "ET plus". ET is associated with abnormal rhythmic activation of the cerebello-thalamo-cortical tremor circuit. Despite its strong heritability, the genetics of ET have not been elucidated as yet. Age-correlated tremor is one of the presumed subgroups of ET. Late onset is associated with a shortened life expectancy. From a treatment perspective, propranolol and primidone represent the drugs of first choice, followed by topiramate. Deep brain stimulation of the Vim nucleus of the thalamus is a proven treatment option in severely affected patients.
PMID: 29404647 [PubMed - as supplied by publisher]

Source: Der Nervenarzt - February 5, 2018 Category: Neurology Authors: Deuschl G, Berg D Tags: Nervenarzt Source Type: research