Compound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer ’s disease

Mouse nicotinamide riboside study shows potential for human research.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news

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Abstract Brief stereotaxic insertion and removal of a microneedle into the hippocampus of mice result in stimulation of hippocampal neurogenesis. This approach has been previously applied to a mouse model of Alzheimer's disease (Song et al., Cell Transplant 25:1853-1861, 2016). Further studies of fundamental cellular mechanisms of the brain's response to micro-injury will be useful for investigation of potential neuroprotective and deleterious effects of targeted microlesions and deep brain stimulation in neurodegenerative diseases. PMID: 30656634 [PubMed - indexed for MEDLINE]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductas...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 14 June 2019Source: Neurología (English Edition)Author(s): T. Casadevall Codina, F. Espada Olivan, C. Guerrero Castaño, N. Ruscalleda Morell
Source: Neurologia - Category: Neurology Source Type: research
AbstractAdult neurogenesis defects have been demonstrated in the brains of Alzheimer ’s disease (AD) patients. The neurogenesis impairment is an early critical event in the course of familiar AD (FAD) associated with neuronal loss. It was suggested that neurologic dysfunction in AD may be caused by impaired functioning of hippocampal neural stem cells (NSCs). Multiple metabolic an d structural abnormalities in neural mitochondria have long been suspected to play a critical role in AD pathophysiology. We hypothesize that the cause of such abnormalities could be defective elimination of damaged mitochondria. In the pre...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Conclusion: Aβ42 and tau seem to be worthy candidates for future salivary biomarkers for AD, but other biomarkers such as lactoferrin and selected metabolites also have potential. More studies must be carried out with larger sample sizes and a standardization of the sampling and processing method. Factors such as diurnal variation, AD patients' decreased ability of oral self-care, and salivary flowrates must be taken into consideration. PMID: 31191751 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Publication date: 15 June 2019Source: New Scientist, Volume 242, Issue 3234Author(s): Debora MacKenzieAn arthritis drug might prevent Alzheimer's, but the firm that owns it isn't keen to develop it. Debora MacKenzie reports
Source: New Scientist - Category: Science Source Type: research
Authors: Rosenberg PB, Outen M S JD, Amjad M D M P H H, Burhanullah M D MH, Vandrey Ph D R, Monette B A PJ, Forester M D M Sc BP PMID: 31196620 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Authors: Wangchuk P, Sastraruji T, Taweechotipatr M, Keller PA, Pyne SG Abstract Corydalis plants containing isoquinoline alkaloids are reported to possess promising phamacological properties for the treatment of important diseases including cancer, inflammation, Alzheimer's disease and microbial infections. As part of a wider program investigating Bhutanese medicinal plants,.we have previously identified eight isoquinoline alkaloids from C. dubia. Out of these, we report here on two of the major alkaloids, scoulerine (1) and cheilanthifoline (2) and their inhibitory activities against acetylcholinesterase (anti-AC...
Source: Natural Product Communications - Category: Biochemistry Tags: Nat Prod Commun Source Type: research
In this study, the activities of N-acetyl chitooligosaccharides (NA-COS), the hydrolytic products of chitin, were evaluated using Aβ-induced damages in animal and cell models of AD. Our results demonstrated that NA-COS significantly improved both acquisition (learning) and retention (memory) of AD rats on water maze task. HE staining of brain tissue sections showed that NA-COS could ameliorate hippocampal neurodegeneration induced by Aβ25-35. Further biochemical analysis showed that NA-COS treatment of intrahippocampal Aβ-microinjected rats was able to elevate choline acetyltransferase activity and attenuate...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li, Zhengxi Hu, Hucheng Zhu, Yonghui ZhangAbstractSpiroterreusnoids A–F, six undescribed spiro-dioxolane-containing adducts bearing 3,5-dimethylorsellinic acid-based meroterpenoid and 2,3-butanediol moieties were isolated from the endophytic fungus Aspergillus terreus Thom from Tripterygium wilfordii Hook. f. (Celastraceae). The structures of these adducts were established by spectroscopy, single-crystal X-ray diffraction, and experime...
Source: Phytochemistry - Category: Chemistry Source Type: research
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