Compound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer ’s disease

Mouse nicotinamide riboside study shows potential for human research.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news

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ABSTRACT Objective Evaluate the accuracy of two semantic categories of the verbal fluency test (supermarket and animal categories) to separate healthy elderly individuals and lower educated Alzheimer ’ s disease patients. Methods We evaluated 69 older adults with less than 5 years of schooling, consisting of 31 healthy elderly, and 38 patients diagnosed with Alzheimer ’ s disease. Semantic verbal fluency was evaluated using the animal and supermarket categories. Mann-Whitney U and Independent t Tests were used to compare the two groups, and the diagnostic accuracy of the tests was analyzed by sensitivity, speci...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Olfactory dysfunction could be an early and reliable indicator for the diagnosis of neurodegenerative disorders such as Alzheimer and Parkinson's diseases. In this paper, we compare the potential of different noninvasive medical imaging modalities (optical coherence tomography, confocal microscopy, and fluorescence endomicroscopy) to distinguish how the olfactory epithelium, both at the cellular and the structural levels, is altered. Investigations were carried out on three experimental groups: two pathological groups (mice models with deliberately altered olfactory epithelium and Alzheimer's disease transgenic mice models...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
Abstract To evaluate functional capacity, mobility and balance in elderly patients with Alzheimer's Disease (AD), in its mild, moderate and severe forms, verifying the existence of correlation among these parameters. Eighty-eight elderly patients (81.79 ± 6.54 years) diagnosed with AD treated at an elderly care reference center in Taguatinga-DF were selected, and information was collected between November 2018 and March 2019. Data collection was initially made by filling in the evaluation form. Subsequently, two questionnaires were administered to caregivers (Clinical Dementia Rating-CDR and Disability Assessment fo...
Source: Revista Brasileira de Cineantropometria e Desempenho Humano - Category: Sports Medicine Source Type: research
Conditions:   Preclinical Alzheimer's Disease;   Early Alzheimer's Disease Interventions:   Drug: BAN2401;   Drug: Placebo Sponsors:   Eisai Inc.;   Alzheimer’s Clinical Trial Consortium (ACTC);   Biogen;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Alzheimer Disease;   Mild Cognitive Impairment Interventions:   Drug: Flortaucipir F18;   Procedure: Brain PET scan Sponsor:   Avid Radiopharmaceuticals Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Preclinical Alzheimer's Disease;   Early Alzheimer's Disease Interventions:   Drug: BAN2401;   Drug: Placebo Sponsors:   Eisai Inc.;   Alzheimer’s Clinical Trial Consortium (ACTC);   Biogen;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Alzheimer Disease;   Mild Cognitive Impairment Interventions:   Drug: Flortaucipir F18;   Procedure: Brain PET scan Sponsor:   Avid Radiopharmaceuticals Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Davis family makes transformative investment to address “one of the greatest, unresolved mysteries of our time”
Source: BWH News - Category: Hospital Management Source Type: news
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those workin...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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