Imaging intralesional heterogeneity of sodium concentration in multiple sclerosis: Initial evidence from 23Na-MRI

Sodium MRI (23Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution 23Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-na ïve relapsing-remitting MS and a ring-enhancing lesion was imaged using 23Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p

Source: Journal of the Neurological Sciences - February 4, 2018 Category: Neurology Authors: James T. Grist, Frank Riemer, Mary A. McLean, Tomasz Matys, Fulvio Zaccagna, Sarah F. Hilborne, Jackie P. Mason, Ilse Patterson, Rhys Slough, Joshua Kaggie, Surrin S. Deen, Martin J. Graves, Joanne L. Jones, Alasdair J. Coles, Ferdia A. Gallagher Tags: Clinical Short Communication Source Type: research