Extruded sorghum flour (Sorghum bicolor L.) modulate adiposity and inflammation in high fat diet-induced obese rats

Publication date: March 2018 Source:Journal of Functional Foods, Volume 42 Author(s): Priscila Marques Arbex, Maria Eliza de Castro Moreira, Renata Celi Lopes Toledo, Leandro de Morais Cardoso, Helena Maria Pinheiro-Sant'ana, Laércio dos Anjos Benjamin, Leandro Licursi, Carlos Wanderlei Piler Carvalho, Valeria Aparecida Vieira Queiroz, Hércia Stampini Duarte Martino The aim was to determine the effect of extruded sorghum flour (ESF) on the adiposity and inflammation modulation in obese Wistar rats. Four experimental groups: normal control (AIN-93), obese control (HFD) and two tested groups (replacing 50% of cellulose and 100% of cornstarch by ESF in the HFD - HFDS50; and replacing 100% of cellulose and 100% of cornstarch by ESF in the HFD - HFDS100) were used. The luteolinidin and 5-methoxy-luteliolinidin were the main deoxyanthocianidins identified in ESF. The Lee index, percentage of adiposity, fatty acid synthase gene expression, TNF-α, blood levels of glucose and the adipocyte hypertrophy were lower in the groups treated with ESF when compared to HFD. The groups treated with ESF up-regulated the lipoprotein lipase, peroxisome proliferator activated receptor-γ gene expression and IL-10. ESF has potential as a functional food since it reduced the metabolic risk of obesity associated with adiposity and inflammation.
Source: Journal of Functional Foods - Category: Nutrition Source Type: research