Mechanism of Action of Cytotoxic Compounds from the Seeds of Euphorbia lathyris

Conclusion : Analysis of the screening data compared with compound structures suggested that the substitutions at C-3, C-5, C-7, and C-15 are critical for cytotoxicity, as well as cell type-selectivity. Furthermore, results of cytotoxic mechanism analysis demonstrated for the first time that compounds 3 and 5 disrupted normal cell cycle progression, whereas compounds 2‒5 induced obvious actin filament aggregation, as well as partial interference of the microtubule network. Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research