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GSE84000 Specific metabolic activation of adipose tissue macrophages during obesity promotes inflammatory responses

Contributors : Lily Boutens ; Guido J Hooiveld ; Rinke StienstraSeries Type : Expression profiling by arrayOrganism : Mus musculusRecent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance, yet changes in their intracellular energy metabolism are currently unknown. We therefore set out to study metabolic signatures of adipose tissue macrophages (ATMs) in lean and obese conditions. F4/80-positive ATMs were isolated from obese vs lean mice. High-fat feeding of wild-type mice and myeloid-specific Hif1 α-/- mice was used to examine the role of hypoxia-inducible factor-1α (HIF-1α) in ATMs part of obese adipose tissue. In vitro, bone marrow-derived macrophages were co-cultured with adipose tissue explants to examine adipose tissue-induced changes in macrophage phenotypes. Transcriptome analysis, real-time flux measurements, ELISA and several other approaches were used to determine the metabolic signatures and inflammatory status of macrophages. In addition, various metabolic routes were inhibited to determine their relevance for cytokine production. Transcriptome analysis and extracellular flux measurements of mouse ATMs revealed unique metabolic rewiring in obesity characterised by both increased glycolysis and oxidative phosphorylation. Simil...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

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Conclusion: Collectively, our results show that palmitate induces CCL4 expression via activation of the TLR4-MyD88/NF-kB/MAPK/ PI3K signaling cascade. Thus, our findings suggest that the palmitate-induced CCL4 production might be an underlying mechanism of metabolic inflammation.Cell Physiol Biochem 2018;46:953 –964
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Authors: Zozina VI, Covantev S, Goroshko OA, Krasnykh LM, Kukes VG Abstract The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Conditions:   Obesity;   Eating Behavior Interventions:   Behavioral: To-Go container;   Other: Control Sponsors:   Penn State University;   United States Department of Agriculture (USDA);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Jenny Craig, Inc. Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
New research suggests that eating breakfast later may drive a preference for late rising and retiring, which is linked to higher BMI in type 2 diabetes.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Diabetes Type 2 Source Type: news
Interleukin 29 activates expression of tissue inhibitor of metalloproteinase 1 in macrophages via toll‑like receptor 2. Mol Med Rep. 2018 Apr 11;: Authors: Zhang H, Song B, He S Abstract Obesity and diabetes are characterized by low grade chronic inflammation status and insulin resistance in adipose tissue associated with metalloproteinase inhibitor 1 (TIMP1). Interleukin (IL)29, exhibits multiple immune regulatory activities. However, the role of IL29 and its effects on TIMP1 remain to be elucidated. The present study was designed to investigate the effects of IL29 on expression of TIMP1 in mac...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
To the Editor: The results of the recent meta-analysis by Bui et  al have confirmed that hidradenitis suppurativa (HS) is significantly associated with an increased prevalence of type 2 diabetes mellitus (T2DM).1 According to the authors, this association could be due to the fact that HS patients tend to be more obese.1 In this regard, we think that altered mech anistic target of rapamycin complex 1 (mTORC1) signaling might contribute and explain the connection between HS and T2DM. mTOR is the core constituent of the phosphatidylinositol 3-kinase–related kinase protein family that forms at least 2 multiprotein c...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD online Source Type: research
Franco Agustín Rascón-Chu Pectins are plant cell wall natural heteropolysaccharides composed mainly of α-1-4 d-galacturonic acid units, which may or may not be methyl esterified, possesses neutral sugars branching that harbor functional moieties. Physicochemical features as pH, temperature, ions concentration, and cosolute presence, affect directly the extraction yield and gelling capacity of pectins. The chemical and structural features of this polysaccharide enables its interaction with a wide range of molecules, a property that scientists profit from to form new composite matrices for targe...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
AbstractPurpose of ReviewSocial media is widely used and has potential to connect adults with obesity with information and social support for weight loss and to deliver lifestyle interventions. The purpose of this review is to summarize recent observational and intervention research on social media and obesity.Recent FindingsOnline patient communities for weight loss abound but may include misinformation. Systematic reviews and meta-analyses suggest that social media-delivered lifestyle interventions modestly impact weight, yet how social media was used and participant engagement varies widely.SummaryThe rapidly changing s...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewA growing number of pediatric acute lymphoblastic leukemia (ALL) and hematopoietic stem cell transplantation (HSCT) survivors reach adulthood and face long-term health-related problems. We review risk factors and the prevalence of the metabolic syndrome (MetS), a cluster of obesity-related comorbidities, including abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, impaired glucose metabolism, and type 2 diabetes in ALL and HSCT survivors.Recent FindingsComponents of the MetS are already detected during the first year of ALL maintenance therapy and significantly worsen over time. ...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewObesity has grown at an alarming rate in children and adolescents. Concurrently, consumption on sugar-sweetened beverages (SSBs) also rose significantly. This review provides an overview of obesity and type 2 diabetes mellitus (T2DM) related to SSBs and current policies restricting SSBs in schools, school-based interventions, and taxation on reducing SSB intake and obesity. We also discuss challenges of and future steps for these initiatives.Recent FindingsClinical and epidemiological studies suggest a strong association between SSB intake and obesity and T2DM. School food policies have been initia...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
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