GSE84000 Specific metabolic activation of adipose tissue macrophages during obesity promotes inflammatory responses

Contributors : Lily Boutens ; Guido J Hooiveld ; Rinke StienstraSeries Type : Expression profiling by arrayOrganism : Mus musculusRecent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance, yet changes in their intracellular energy metabolism are currently unknown. We therefore set out to study metabolic signatures of adipose tissue macrophages (ATMs) in lean and obese conditions. F4/80-positive ATMs were isolated from obese vs lean mice. High-fat feeding of wild-type mice and myeloid-specific Hif1 α-/- mice was used to examine the role of hypoxia-inducible factor-1α (HIF-1α) in ATMs part of obese adipose tissue. In vitro, bone marrow-derived macrophages were co-cultured with adipose tissue explants to examine adipose tissue-induced changes in macrophage phenotypes. Transcriptome analysis, real-time flux measurements, ELISA and several other approaches were used to determine the metabolic signatures and inflammatory status of macrophages. In addition, various metabolic routes were inhibited to determine their relevance for cytokine production. Transcriptome analysis and extracellular flux measurements of mouse ATMs revealed unique metabolic rewiring in obesity characterised by both increased glycolysis and oxidative phosphorylation. Simil...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

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This study specifically analyzes the correlation between income inequality, measured by state-level Gini coefficients from the American Community Survey (ACS), and individual behavioral, physical, and mental health outcomes from the Behavioral Risk Factor Surveillance System (BRFSS) for 2006 through 2014. After controlling for demographic and socioeconomic characteristics, health insurance status, year trends, and state fixed effects, income inequality was found to have significant relationships with behavioral, physical, and mental health outcomes, including heavy drinking, obesity, exercise, diabetes, heart attack, heart...
Source: The Social Science Journal - Category: Psychiatry & Psychology Source Type: research
Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Susan Westfall, Nikita Lomis, Satya PrakashAbstractImbalances in the gut microbiota are directly associated with the pathogenesis of diabetes and obesity. The current study investigates how the combination of three probiotics Lactobacillus plantarum NCIMB 8826, L. fermentum NCIMB 5221 and Bifidobacteria longum subsp. infantis NCIMB 702255 with a novel polyphenol-rich prebiotic Triphala has combinatorial benefits on the symptoms and underlying mechanisms of diet-induced diabetes and obesity. Drosophila melanogaster fed either a high-fat...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Conclusion: MS disorders are frequent in this population and associated with various factors. HbA1c level does not appear to be associated with development of MS disorders. PMID: 30018643 [PubMed]
Source: International Journal of Rheumatology - Category: Rheumatology Tags: Int J Rheumatol Source Type: research
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Source: Recent Patents on Food, Nutrition and Agriculture - Category: Food Science Tags: Recent Pat Food Nutr Agric Source Type: research
Publication date: Available online 19 July 2018Source: Obesity Research &Clinical PracticeAuthor(s): Michelle Kilpatrick, Mark Nelson, Andrew Palmer, Kim Jose, Alison VennAbstractObjectiveGeneral practitioners (GPs) can positively impact upon patient intentions to lose weight and weight management, and are important in the referral pathway to specialist weight-loss programs and surgical interventions. The aim of this study was to investigate the characteristics and proportions of Australians who report talking to a GP about weight management.MethodsCross-sectional data from 15,329 participants aged 15 years and over in...
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
To investigate future diabetes in different abdominal obesity phenotypes during 12 years of follow-up.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Three GPs form part of new 20-strong cohort of champions Related items fromOnMedica More Scottish GPs needed to fight heart disease GPs to receive help to improve patients ’ physical activity Put families at heart of helping obese children Apply different obesity criteria to BME patients GPs should recommend gradual, long-term weight loss
Source: OnMedica Latest News - Category: UK Health Source Type: news
In this study, we investigated the short-term prognostic value of early measurement of irisin concentration in 1530 Han Chinese patients with acute ischemic stroke (AIS) from three stroke centers. The subjects were the first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Clinical information and stroke severity were collected at admission. Neurological evaluations were conducted at the 6-month follow-up. Serum levels of irisin, National Institutes of Health Stroke Scale (NIHSS), and conventional risk factors were evaluated to determine their value to pr...
Source: Neurotherapeutics - Category: Neurology Source Type: research
Dysregulation of the circadian rhythm is associated with many diseases, including diabetes, obesity, and cancer. Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl or Bmal1) is the only clock gene whose loss disrupts circadian locomotor behavior in constant darkness. BMAL1 levels are affected by proteasomal inhibition and by several enzymes in the ubiquitin–proteasome system, but the exact molecular mechanism remains unclear. Here, using immunoprecipitation and MS analyses, we discovered an interaction between BMAL1 and ubiquitin-conjugating enzyme E2 O (UBE2O), an E3-independent E2 ubiquitin–...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Protein Synthesis and Degradation Source Type: research
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