Sinomenine inhibits fibroblast-like synoviocyte proliferation by regulating α7nAChR expression via ERK/Egr-1 pathway.

In conclusion, the expression of α7nAChR involved in the aggressive proliferation of FLS induced by TNF-α and was regulated by ERK/Egr-1 signal pathway. SIN inhibited FLS proliferation and α7nAChR expression through inhibiting ERK/Egr-1 signal pathway, this may contribute to the anti-inflammatory and anti-arthritic effect of SIN.
PMID: 29367088 [PubMed - as supplied by publisher]

Source: International Immunopharmacology - January 20, 2018 Category: Allergy & Immunology Authors: Yi L, Lyn YJ, Peng C, Zhu RL, Bai SS, Liu L, Wang PX, Zhou H, Dong Y Tags: Int Immunopharmacol Source Type: research