Cancers, Vol. 10, Pages 27: Analysis of Site-Specific Methylation of Tumor-Related Genes in Head and Neck Cancer: Potential Utility as Biomarkers for Prognosis
Cancers, Vol. 10, Pages 27: Analysis of Site-Specific Methylation of Tumor-Related Genes in Head and Neck Cancer: Potential Utility as Biomarkers for Prognosis
Cancers doi: 10.3390/cancers10010027
Authors:
Kiyoshi Misawa
Daiki Mochizuki
Atsushi Imai
Masato Mima
Yuki Misawa
Hiroyuki Mineta
Clarifying the epigenetic regulation of tumor-related genes (TRGs) can provide insights into the mechanisms of tumorigenesis and the risk for disease recurrence in HPV-negative head and neck cancers, originating in the hypopharynx, larynx, and oral cavity. We analyzed the methylation status of the promoters of 30 TRGs in 178 HPV-negative head and neck cancer patients using a quantitative methylation-specific PCR. Promoter methylation was correlated with various clinical characteristics and patient survival. The mean number of methylated TRGs was 14.2 (range, 2–25). In the multivariate Cox proportional hazards analysis, the methylation of COL1A2 and VEGFR1 was associated with poor survival for hypopharyngeal cancer, with hazard ratios: 3.19; p = 0.009 and 3.07; p = 0.014, respectively. The methylation of p16 and COL1A2 were independent prognostic factors for poor survival in laryngeal cancer (hazard ratio: 4.55; p = 0.013 and 3.12; p = 0.035, respectively). In patients with oral cancer, the methylation of TAC1 and SSTR1 best correlated with poor survival (hazard ratio: 4.29; p = 0.005 and 5.38; p = 0.029, respectively). Our findings suggest that methylation status of TRGs ...
Source: Cancers - Category: Cancer & Oncology Authors: Kiyoshi Misawa Daiki Mochizuki Atsushi Imai Masato Mima Yuki Misawa Hiroyuki Mineta Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Genetics | Head and Neck Cancer | Hypopharyngeal Cancer | Laryngeal Cancer | Oral Cancer | Oral Cavity Cancer