Prolonging ticagrelor beyond a year of acute coronary syndrome: worth or harmful?
Prolonging ticagrelor beyond a year of acute coronary syndrome: worth or harmful?
Curr Vasc Pharmacol. 2018 Jan 16;:
Authors: Aradi D, Dezsi D, Veress G, Merkely B
Abstract
Platelet activation plays a central role in triggering and complicating acute coronary syndromes, especially in case of stent thrombosis and myocardial infarction. On top of aspirin, P2Y12-inhibitors are successfully used to treat and prevent these events for a duration of one year after an acute coronary episode or 6 months after drug-eluting stent implantation. However, patients with acute coronary syndromes remain at heightened risk for recurrent ischemic events after the recommended durations of P2Y12-inhibitors and therefore, prolonging treatment is often considered in clinical practice. However, the higher risk for bleeding limits the utility of such approach to a restricted group who is still poorly defined by available measures. This review aims to discuss potential benefits and highlight important pitfalls of prolonged treatment with P2Y12-inhibitors, with a focus on ticagrelor, an attractive reversible P2Y12-inhibitor in patients after myocardial infarction.
PMID: 29345592 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Aradi D, Dezsi D, Veress G, Merkely B Tags: Curr Vasc Pharmacol Source Type: research