Role of the microbiota in cancer growth and necrosis: the challenges and opportunities of bacteriotherapy for cancer and its complications

Possessing a selective growth advantage by influencing proliferation barrier, immune system, metabolism, and cell proliferation and death in tissues, is a critical event in cancer formation, progression, and suppression, indicating that specific microbes and microbiotas may enhance or dwindle cancer susceptibility. A host's microbiota may affect not only immune responses in developing tumor environment by inducing proinflammatory or immunosuppressive events but also response to cancer diagnosis, treatment, and relevant complications. As gifts to both cancer biology and microbiology, increased interrogating technologies have shed light on host–microbiota interactions and their roles in human health and disease. The interacting network of cancer, host, and microbial genotypes is identified in this review to assess how microorganism may play an important role in carcinogenesis, developing novel therapeutic and diagnostic strategies for cancer and its complications.
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: Bacteriology Source Type: research