New insights into the role of renal resident cells in the pathogenesis of lupus nephritis.

New insights into the role of renal resident cells in the pathogenesis of lupus nephritis.
Korean J Intern Med. 2018 Jan 12;:
Authors: Kwok SK, Tsokos GC
Abstract
Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SLE is complex and most clinical trials of biologics targeting immune cells or their mediators have failed to show efficacy in SLE patients. It has therefore become increasingly clear that additional, local factors give rise to the inflammation and organ damage. In this review, we describe recent advances in the role of renal resident cells, including podocytes, mesangial cells, and epithelial cells, in the pathogenesis of lupus nephritis.
PMID: 29320847 [PubMed - as supplied by publisher]

Source: The Korean Journal of Internal Medicine - January 12, 2018 Category: Internal Medicine Authors: Kwok SK, Tsokos GC Tags: Korean J Intern Med Source Type: research