Diagnostic Usefulness of Combination of Diffusion-weighted Imaging and T2WI, Including Apparent Diffusion Coefficient in Breast Lesions

Conclusion Combining DWI, T2WI, and ADC values provides increased accuracy for differentiation between benign and malignant lesions, compared with DCE-MRI. A lower ADC value was associated with a higher histologic grade cancer.
Source: Academic Radiology - Category: Radiology Source Type: research

Related Links:

In this study, a simple but sensitive electrochemiluminescence (ECL) biosensor has been designed for HAase detection based on the electrostatic interaction of anionic hyaluronic acid (HA) and cationic luminous reagent Ru(bpy)32+. Ru(bpy)32+ is adsorbed on HA through electrostatic interaction to form HA-Ru(bpy)32+ complex. The Ru(bpy)32+ in the HA-Ru(bpy)32+ complex cannot be filtered out because of its large molecular weight. In the presence of HAase, the HA in HA-Ru(bpy)32+ can be cleaved into fragments by enzymatic hydrolysis. As a result, the Ru(bpy)32+ attached on the HA fragments can be separated from the HA-Ru(bpy)32...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: 1 November 2018Source: Inorganica Chimica Acta, Volume 483Author(s): Yeşim Salman, Fırat Barış Barlas, Murat Yavuz, Kerem Kaya, Suna Timur, Fatma Çetin TelliAbstractFour novel dinuclear Cu(II) complexes (1a–4a) have been prepared from ONO-tridentate chiral Schiff base derivatives of chloralose (1–4). All the new complexes (1a–4a) have been characterized by Fourier transform infrared spectroscopy, UV–visible spectroscopy and elemental analysis. The complex 2a was further characterized by X-Ray crystallography. And also, the magnetic susceptibility measurement of this comp...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Reese Witherspoon and Keith Urban are among the stars joining the sixth Stand Up To Cancer telethon on Sept. 7.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
BOWEL cancer risk could be reduced by making some diet or exercise changes. Eating more of this cheap vegetable could prevent the deadly disease, scientists have claimed. Its preventative effects are “striking”, they said.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
To outwit cancer, researchers are working on better ways to teach patients' immune system to root out and kill malignant cells. A promising approach involves cells that attack cancer two ways at once.(Image credit: Pearl Mak/NPR)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
In this study, we sought to further describe clinicopathologic findings in a large series of ACD-RCC, emphasizing histologic features, immunophenotype, clinical outcome, and patterns of disease spread. We collected 40 previously unpublished cases of ACD-RCC with mean clinical follow-up of 27 months (median, 19 mo; range, 1 to 126 mo). Mean tumor size was 2.7 cm (median, 2.4 cm), and 32 tumors (80%) were confined to the kidney (pT stage less than pT3a). International Society of Urological Pathology grade was 3 in 37 cases (92.5%), grade 2 in 1 case (2.5%), and grade 4 in 2 cases (5%). Architectur...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC) has recently been described as a potentially new subtype of RCC based upon morphologic and immunohistochemical features. These neoplasms typically demonstrate solid and cystic architecture, and the neoplastic cells contain voluminous eosinophilic cytoplasm with granular cytoplasmic stippling. There is frequently focal immunoreactivity for cytokeratin 20. Although the initial cases all occurred in adult females and had benign outcome, we recently expanded the proposed spectrum of this neoplasm to include pediatric cases, multifocal neoplasms, and a case with hem...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
We describe a novel gene fusion, EWSR1-CREM, identified in 3 cases of clear cell carcinoma (CCC) using anchored multiplex polymerase chain reaction, a next-generation sequencing–based technique. CCC is a low-grade salivary tumor recently characterized to have EWSR1-ATF1 fusions in the majority of cases. Three cases of malignant tumor presenting in the base of tongue, lung, and nasopharynx were studied. All cases shared a clear cell morphology with hyalinized stroma, presence of mucin and p63 positivity and were initially diagnosed as mucoepidermoid carcinoma but were negative for evidence of any of the expected gene ...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
The American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) 2013 guidelines for HER2 assessment have increased the number of HER2 equivocal breast carcinomas following in situ hybridization reflex testing, that is, HER2 “double equivocal” (equivocal protein expression and equivocal gene copy number). Forty-five double-equivocal carcinomas were subjected to Prosigna analysis. Twenty-seven cases were investigated for the expression of genes found to be differentially expressed between estrogen receptor (ER)-positive/HER2-positive (N=22) and ER-positive/HER2-negative (N=22) control cases....
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
More News: Academia | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Carcinoma in Situ | DCIS (Ductal Carcinoma in Situ) | Ductal Carcinoma | Lobular Carcinoma | MRI Scan | Mucinous Carcinoma | Radiology | Study