Cancers, Vol. 10, Pages 19: EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs
Cancers, Vol. 10, Pages 19: EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs
Cancers doi: 10.3390/cancers10010019
Authors:
Joanna Macdonald
Justin Henri
Kislay Roy
Emma Hays
Michelle Bauer
Rakesh Veedu
Normand Pouliot
Sarah Shigdar
The epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In the last forty years, this biomarker has been investigated for use in personalized cancer therapy, with the first monoclonal antibody, edrecolomab, being trialled in humans more than thirty years ago. Since then, several other monoclonal antibodies have been raised to EpCAM and tested in clinical trials. However, while monoclonal antibody therapy has been investigated against EpCAM for almost 40 years as primary or adjuvant therapy, it has not shown as much promise as initially heralded. In this review, we look at the reasons why and consider alternative targeting options, such as aptamers, to turn this almost ubiquitously expressed epithelial cancer biomarker into a viable target for future personalized therapy.
Source: Cancers - Category: Cancer & Oncology Authors: Joanna Macdonald Justin Henri Kislay Roy Emma Hays Michelle Bauer Rakesh Veedu Normand Pouliot Sarah Shigdar Tags: Review Source Type: research
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