Patient‐Reported Symptom Control of Diarrhea and Flushing in Patients with Neuroendocrine Tumors Treated with Lanreotide Depot/Autogel: Results from a Randomized, Placebo‐Controlled, Double‐Blind and 32‐Week Open‐Label Study

Conclusion.Improved diarrhea and flushing control in CS patients during 16‐week lanreotide treatment was sustained during maintenance of lanreotide treatment for the 32‐week IOL phase (48 weeks total).Implications for Practice.This study prospectively collected daily patient‐reported data on diarrhea and flushing from the ELECT trial to evaluate the direct impact of lanreotide depot on patients’ relief of carcinoid syndrome symptoms. Treatment with lanreotide depot was associated with significant reductions in the percentages of days patients reported symptoms of diarrhea and flushing, as well as reductions in the frequency and severity of daily symptoms compared with placebo during 16 weeks of double‐blind treatment. These improvements were sustained for 32 additional weeks of open‐label lanreotide treatment (i.e., through week 48 of treatment), resulting in clinically meaningful, long‐term symptom reduction.

Source: The Oncologist - January 9, 2018 Category: Cancer & Oncology Authors: George A. Fisher, Jr., Edward M. Wolin, Nilani Liyanage, Susan Pitman Lowenthal, Beloo Mirakhur, Rodney F. Pommier, Montaser Shaheen, Aaron Vinik, on behalf of the ELECT Study Group Tags: Symptom Management and Supportive Care, Gastrointestinal Cancer Source Type: research