Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease

Background: Although no receptor has yet been identified, changes in circulating levels of the adipokine designated as Omentin have been demonstrated in obesity and related comorbidities such as cardiovascular disease, insulin resistance, metabolic syndrome and chronic inflammation. Methods: Changes in Omentin levels at 1 and 5?days and 6 and 12?months in response to biliopancreatic diversion with duodenal switch bariatric surgery were evaluated, specifically to investigate if changes preceded gain of insulin sensitivity. Results: Pre-operative plasma Omentin was not different between men (n?=?18) vs women (n?=?48), or diabetic status but correlated with body mass index (BMI). Altogether, Omentin increased as early as 24-h post-surgery, with changes maintained up to 1-year. Fifty-nine percent of subjects increased Omentin >10% by 24-H following surgery (OmentinINC p?
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research