Genetic variants demonstrating flip-flop phenomenon and breast cancer risk prediction among women of African ancestry

ConclusionsWe found that PRS based on variants identified from prior GWASs conducted in women of European and Asian ancestries did not provide a comparable degree of risk stratification for women of African ancestry. Further large-scale fine-mapping studies in African ancestry populations are desirable to discover population-specific genetic risk variants.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research