Blood Levels of Caffeine May Help Diagnose Parkinson ’s (CME/CE)

(MedPage Today) -- Study finds decreased metabolites in early disease, regardless of caffeine consumption
Source: MedPage Today Neurology - Category: Neurology Source Type: news

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AbstractThe concept of personalised medicine in Parkinson ’s disease has arrived where the implications of findings made in research are certain to have an increasing impact upon clinical practice. Disease heterogeneity in Parkinson’s disease has been well described and lends itself to the construct of personalised medicine where it is hypothesised tha t a greater understanding of genetic and pathophysiological contributions may underpin the sub-groups described. This in turn has driven the development of potentially individualised disease-modifying therapies where, for example, we are beginning to see treatmen...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
2 teams find that inhibiting stearoyl-CoA desaturase reduces the toxicity of α-synuclein, a protein implicated in Parkinson’s disease
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was suffic...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
IJERPH, Vol. 15, Pages 2885: Estimated Residential Exposure to Agricultural Chemicals and Premature Mortality by Parkinson’s Disease in Washington State International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15122885 Authors: Mariah Caballero Solmaz Amiri Justin T. Denney Pablo Monsivais Perry Hystad Ofer Amram The aim of this study was to examine the relationship between estimated residential exposure to agricultural chemical application and premature mortality from Parkinson’s disease (PD) in Washington State. Washington State mortality records for 2011&...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In this study, we have manipulated CMA function through alterations of LAMP2A abundance of utilizing primary rat cortical neurons, to identify potential changes to the neuronal proteome occurring prior to actual toxic effects. We have identified a list of proteins with significant,>2-fold change in abundance following our manipulations, of which PARK7/DJ-1 – an anti-oxidant implicated in hereditary forms of Parkinson's Disease (PD), and DPYSL2/CRMP-2 – a microtubule-binding phosphoprotein involved in schizophrenia pathogenesis – were both found to have measurable effects on neuronal homeostasis and phe...
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
BACKGROUND: Parkinson's Disease (PD) is a chronic neurodegenerative disease associated with motor problems such as gait impairment. Different systems based on 3D cameras, accelerometers or gyroscopes have been used in related works in order to study gait d...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Publication date: Available online 14 December 2018Source: Neurochemistry InternationalAuthor(s): Bruk Getachew, Antonei B. Csoka, Michael Aschner, Yousef TizabiAbstractManganese (Mn) and iron (Fe) are trace elements that are essential for proper growth and physiological functions as both play critical role in a variety of enzymatic reactions. At high concentrations, however, they can be toxic and cause neurodegenerative disorders, particularly Parkinson-like syndromes. Nicotine, on the other hand, has been shown to have neuroprotective effects against various endogenous or exogenous toxins that selectively damage the dopa...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Postural control asymmetry is an important aspect of Parkinson's disease (PD) that may be associated with falls. The aim of this study was to compare the postural control asymmetry during postural tasks between fallers and non-fallers in people with PD and...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conditions:   Parkinson Disease;   Movement Disorders;   Neuro-Degenerative Disease;   Nervous System Diseases;   Brain Diseases Interventions:   Drug: Cerebral Dopamine Neurotrophic Factor;   Device: Renishaw Drug Delivery System Sponsors:   Herantis Pharma Plc.;   Renishaw plc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson Disease Intervention:   Procedure: Lumbar Puncture Sponsors:   Michael J. Fox Foundation for Parkinson's Research;   University Health Network, Toronto;   Indiana University;   Clinical Trials Coordination Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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