Blood Levels of Caffeine May Help Diagnose Parkinson ’s (CME/CE)

(MedPage Today) -- Study finds decreased metabolites in early disease, regardless of caffeine consumption
Source: MedPage Today Neurology - Category: Neurology Source Type: news

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Authors: Yin Y, Wang Z Abstract Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE has three isoforms, ApoE2, ApoE3, and ApoE4, which are expressed by the polymorphic alleles: ɛ2, ɛ3, and ɛ4. Among the three polymorphic alleles, apoE ε4 is the most risk gene. ApoE is the main ligand for the low-density lipoprotein (LDL) receptor and the LDL receptor-related protein (LRP), functioning as the component of plasma lipoproteins in the transportation of lipids. Physiologically, ApoE is a multifunc...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionA new robust and reliable rating scale is described that straightforwardly captures the visual appearance of 123I-Ioflupane brain images. It demonstrated high accuracy in autopsy confirmed cases and offers advantages over the existing visual rating scale.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
(MedPage Today) -- Meta-analysis finds inverse dose-response link between activity and PD risk
Source: MedPage Today Neurology - Category: Neurology Source Type: news
Publication date: Available online 20 September 2018Source: International Review of NeurobiologyAuthor(s): Nicolaas I. Bohnen, Prabesh Kanel, Martijn L.T.M. MüllerAbstractOne of the first identified neurotransmitters in the brain, acetylcholine, is an important modulator that drives changes in neuronal and glial activity. For more than two decades, the main focus of molecular imaging of the cholinergic system in Parkinson's disease (PD) has been on cognitive changes. Imaging studies have confirmed that degeneration of the cholinergic system is a major determinant of dementia in PD. Within the last decade, the focus is...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 20 September 2018Source: NeurocomputingAuthor(s): Bangming Gong, Jun Shi, Shihui Ying, Yakang Dai, Qi Zhang, Yun Dong, Hedi An, Yingchun ZhangAbstractNeuroimaging has shown its effectiveness for diagnosis of Parkinson's disease (PD), and the neuroimaging-based computer-aided diagnosis (CAD) then attracts considerable attention. In a CAD system, the classifier module is one of the key components, which directly decides the classification performance. As a newly proposed classifier, the large margin distribution machine (LDM) has excellent generalization by maximizing the margin mean and mi...
Source: Neurocomputing - Category: Neuroscience Source Type: research
The objective of this review is to summarize evidences emerged from clinical studies that have demonstrated the efficacy of ISD in advanced parkinsonian patients. It will then focus on the potential role in treating non-motor symptoms and cognitive decline, which heavily affect quality of life for PD patients. Its putative role as neuroprotective agent will also be discussed. Expert Opinion: ISD might represent an alternative option for patients with advanced PD. The reduction of OFF time highlighted in pivotal trials is comparable to that obtained with different levodopa adjunct therapies. The low profile of side effects ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Authors: Yang Y, Xue LJ, Xue X, Ou Z, Jiang T, Zhang YD Abstract A number of studies indicated that apoptosis, a specific type of programmed cell death, contributed to the loss of dopaminergic neurons during progression of Parkinson's disease (PD). Previously, the authors of the present study demonstrated that apoptosis of dopaminergic neurons was mainly achieved via the mitochondria-mediated apoptosis pathway, however, the precise molecular mechanisms remain to be elucidated. The present study aimed to determine whether mitofusin-2 (MFN2), a mitochondrial protein, participated in the apoptosis of dopaminergic neur...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
AIM: In this pilot study, we evaluated the feasibility, safety and preliminary efficacy of a 6-week, community-based group intervention designed to reduce freezing of gait (FOG) for people with Parkinson's disease (PD). METHODS: Seven people with P...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conditions:   Parkinson Disease;   Cognitive Impairment Interventions:   Behavioral: Working memory updating training;   Behavioral: Placebo training Sponsors:   Umeå University;   Karlstad University Recruiting
Source: - Category: Research Source Type: clinical trials
In this paper, we develop new methods to automatically detect the onset and duration of freezing of gait (FOG) in people with Parkinson disease (PD) in real time, using inertial sensors. We first build a physical model that describes the trembling motion during the FOG events. Then, we design a generalized likelihood ratio test framework to develop a two-stage detector for determining the zero-velocity and trembling events during gait. Thereafter, to filter out falsely detected FOG events, we develop a point-process filter that combines the output of the detectors with information about the speed of the foot, provided by a...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
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