MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor.

CONCLUSION: The key findings of this study provided evidence suggesting that miR-152 functions by means of binding to CTSL to induce GIST cell apoptosis and inhibit proliferation, migration, and invasion. The anti-tumor role of miR-152 makes it an attractive therapeutic target for GIST. PMID: 29278883 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29278883?dopt=Abstract

Source: Cancer Biomarkers : Section A of Disease Markers - December 15, 2017 Category: Cancer & Oncology Authors: Lu HJ, Yan J, Jin PY, Zheng GH, Qin SM, Wu DM, Lu J, Zheng YL Tags: Cancer Biomark Source Type: research