[Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach].

[Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach]. Acta Med Port. 2017 Oct 31;30(10):742-749 Authors: Martins P, Castela E, Rocha G, Sena C, Seiça R Abstract Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. The clinical approach to this population in terms of cardiovascular prevention is mainly based on efficient treatment of the infection, reduction of the modifiable risk factors and promotion of lifestyle changes. PMID: 29268069 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research