GSE106106 mRNA differencial expression data between scrambled siRNA-treated mice and HN1L siRNA-treated mice tumor samples

Contributors : Jenny C Chang ; Stephen Wong ; Yi Liu ; Dong S Choi ; Helen Wong ; Yang Cong ; Jianting ShengSeries Type : Expression profiling by arrayOrganism : Homo sapiens(HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free survival in triple negative breast cancer (TNBC) patients. HN1L silencing reduced the population of BCSCs, inhibited tumor initiation, re-sensitized chemo-resistant tumors to docetaxel, and hindered cancer progression in multiple TNBC cell line derived xenografts.We used microarray to compare mRNA expression profiles from PDX BCM2665 xenograft tumors with or without HN1L knockdown, to identify role of HN1L in regulating cancer stem cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research