Regional and long-range neural synchronization abnormality during passive hyperthermia.

Regional and long-range neural synchronization abnormality during passive hyperthermia.
Behav Brain Res. 2017 Dec 13;341:9-15
Authors: Han W, Qian S, Jiang Q, Liu K, Li B, Sun G
Abstract
Passive hyperthermia would impair wide-domain cognitive performances (e.g. attention, working memory), which may involve abnormal regional and long-range neural activity. Combining the regional homogeneity (ReHo) and seed-based functional connectivity analysis, this study investigated the regional and long-range neural synchronization abnormality during passive hyperthermia. We acquired the resting-state blood oxygenation level dependent (BOLD) data from twenty-three healthy male participants in two simulated thermal conditions: normothermic condition (NC) with temperature at 25°C for 1 h and hyperthermic condition (HC) with temperature at 50°C for 1 h. After scanning, participants were asked to perform an attention network test (ANT). Relative to NC participants, the participants in HC group exhibited decreased regional neural synchronization in the frontal-occipital cortex, specifically in the left opercular part of inferior frontal gyrus/insula, bilateral middle occipital gyrus, and posterior cingulate cortex/precuneus, but increased one in the left dorsal superior/middle frontal gyrus. Using these significantly differed ReHo clusters as seeds, we further performed functional connectivity analysis and found aberrant long-range neural synchro...

Source: Behavioural Brain Research - December 13, 2017 Category: Neurology Authors: Han W, Qian S, Jiang Q, Liu K, Li B, Sun G Tags: Behav Brain Res Source Type: research