Therapy ‐Related Acute Myeloid Leukaemia and Myelodysplastic Syndrome in Victoria, Australia 2003‐2014

ConclusionsThe burden of tAML/tMDS in Victoria is likely to be underestimated. Linkage between VCR and clinical registries is needed to provide more accurate insights.
Source: Internal Medicine Journal - Category: Internal Medicine Authors: Tags: Original Article Source Type: research

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Publication date: 15 January 2019Source: Journal of Molecular Structure, Volume 1176Author(s): S. Murugavel, C. Ravikumar, G. Jaabil, Ponnusamy AlagusundaramAbstractPrevious research studies confirm that molecules containing 1,2,3-triazole moiety are potential anticancer agents which elevates effectiveness and reduces drug resistance. Present study was aimed to evaluate the anticancer activity of the synthesized novel title compound 2-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-4-(2-chlorophenyl)-6-methoxypyridine (BTCP). The structural and spectral characteristics of BTCP were studied and compared with DFT results. NBO, HOM...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 September 2018Source: Advances in Biological RegulationAuthor(s): Mariana L. Oliveira, Padma Akkapeddi, Daniel Ribeiro, Alice Melão, João T. BarataAbstractInterleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration and resistance to chemotherapy. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, u...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Simon Thompson, 32, from Kent, was rushed to hospital when a 'dental abscess' failed to improve despite antibiotics. He was later diagnosed with advanced Non Hodgkin's lymphoma.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
From 2011 to 2016, expenditure on cancer drugs in the United States rapidly accelerated. The first prospective study of its kind tallies the numbers.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Authors: Hilpert F, Du Bois A Abstract INTRODUCTION: Patient-reported outcomes (PROs), including quality-of-life considerations, are increasingly becoming key factors in clinical decision making. Areas covered: This review provides an overview of the current status of PROs in guiding clinical trial design and clinical decision making in patients with ovarian cancer and previews the future potential of PROs in these settings. Expert commentary: In ovarian cancer, considerable discord exists between patients and physicians regarding perceived symptom burden. During maintenance therapy, it is important that the most a...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
CONCLUSION: Trabectedin + PLD may be an option for patients with platinum-sensitive relapsed ovarian cancer, including those who have received two or more previous lines of platinum. PMID: 30223697 [PubMed - in process]
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Authors: Ray-Coquard I Abstract OBJECTIVE: In patients with recurrent ovarian cancer, there are certain situations where further surgery and/or next-line platinum-based chemotherapy is not feasible or is not the best option. Multidisciplinary teams have a key role in reviewing available options and selecting the most appropriate intervention. METHODS: A case study of relapsed ovarian cancer illustrates some of the factors that shape decision-making and shows the potential of a non-platinum-based regimen in the context of limited platinum sensitivity. RESULTS: Taking into account the patient's individual cir...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Recurrent ovarian cancer 8 months after induction and bevacizumab consolidation: rationale for using trabectedin + pegylated liposomal doxorubicin in second line. Expert Rev Anticancer Ther. 2018 Oct;18(sup1):13-17 Authors: Colombo N Abstract OBJECTIVES: Ovarian cancer patients with relapse 6-12 months after last platinum treatment, who have received bevacizumab consolidation and are not BRCA mutant, represent a considerable therapeutic challenge. METHODS: By means of illustrative case study, this review evaluates various treatment strategies for use at first relapse in an ovarian ca...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Publication date: Available online 20 September 2018Source: Urology PracticeAuthor(s): Alice Semerjian, Antonio R.H. Gorgen, C.J. Stimson, Stephen A. Boorjian, Christian P. PavlovichAbstractPurposeTo assess fellowship impact on subsequent practice type and case-mix, we compared urologists who completed a urologic oncology fellowship (OF) to urologists who did not complete a fellowship (NF).Materials and MethodsAnnualized case log data were obtained from the American Board of Urology from 2004 to 2016, including initial certification (C1) and re-certifications 1 (R1) and 2 (R2). We evaluated trends in major urologic oncolog...
Source: Urology Practice - Category: Urology & Nephrology Source Type: research
ConclusionsThough decreasing utilization of low-value services is a fundamental goal of ACOs, PSA screening and prostate biopsy trends were similar for ACO and non-ACO providers across all age groups in the study years. This suggests that ACO implementation did not have an impact on PSA screening or prostate biopsies usage.
Source: Urology Practice - Category: Urology & Nephrology Source Type: research
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