Familial tauopathy with P364S MAPT mutation: clinical course, neuropathology and ultrastructure of neuronal tau inclusions

ConclusionsP364S MAPT mutation is characterized clinically by a variable combination of frontotemporal dementia, parkinsonism and motor neuron disease of short duration, and neuropathologically by a widespread uniform distribution of all known neuronal tau inclusions in one family member. Two‐compartment CNTI is a unique characteristic of the P364S MAPT mutation.This article is protected by copyright. All rights reserved.

Source: Neuropathology and Applied Neurobiology - December 7, 2017 Category: Neurology Authors: Peter Štrafela, Jerica Pleško, Jožef Magdič, Blaž Koritnik, Andrej Zupan, Damjan Glavač, Mara Bresjanac, Mara Popović Tags: Original Article Source Type: research