Gene Mutations as Emerging Biomarkers and Therapeutic Targets for Relapsed Acute Myeloid Leukemia

Habsah Aziz, Chow Y. Ping, Hamidah Alias, Nurul-Syakima Ab Mutalib, Rahman Jamal
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Conclusion: A combined diagnostic approach including biochemical, microbiological and pathological evaluation was useful in eliminating infectious meningitis and confirming neoplastic meningitis in these cases. Cytology should be performed on cerebrospinal specimens from all patients with known or suspected malignancy with meningismus. Detection of malignant cells on cytological examination of CSF is the diagnostic gold standard for neoplastic meningitis.
Source: Journal of Cytology - Category: Cytology Authors: Source Type: research
Preconditioning with fludarabine, busulfan and cytarabine versus standard BuCy2 for patients with acute myeloid leukemia: a prospective, randomized phase II study, Published online: 19 October 2018; doi:10.1038/s41409-018-0356-5Preconditioning with fludarabine, busulfan and cytarabine versus standard BuCy2 for patients with acute myeloid leukemia: a prospective, randomized phase II study
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens, Published online: 19 October 2018; doi:10.1038/s41408-018-0134-zLow-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens
Source: Blood Cancer Journal - Category: Hematology Authors: Source Type: research
Authors: Liu C, Han M, Zhao L, Zhu M, Xu Q, Song Y, Wang H Abstract OBJECTIVE: This research aimed to explore the significance of low activity of ADAMTS-13 in acute myeloid leukemia (AML) after bone morrow transplantation (BMT), and to evaluate the disease progress and prognosis of the patients with low or normal activity of ADAMTS-13 after BMT. METHODS: 46 AML patients were included in our research. ADAMTS-13 activity was measured before BMT. Their medical indicators were recorded one month after BMT. All the patients were followed up and their disease progression was evaluated afterwards. The medical indicato...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Cytometry Part B: Clinical Cytometry, EarlyView.
Source: Cytometry Part B: Clinical Cytometry - Category: Molecular Biology Authors: Source Type: research
British Journal of Haematology, EarlyView.
Source: British Journal of Haematology - Category: Hematology Authors: Source Type: research
Molecular measurable residual disease (MRD) assessment is not established in approximately 60% of acute myeloid leukemia (AML) patients because of the lack of suitable markers for quantitative real-time polymerase chain reaction. To overcome this limitation, we established an error-corrected next-generation sequencing (NGS) MRD approach that can be applied to any somatic gene mutation. The clinical significance of this approach was evaluated in 116 AML patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) in complete morphologic remission (CR). Targeted resequencing at the time of diagnosis identified...
Source: Blood - Category: Hematology Authors: Tags: Transplantation, Myeloid Neoplasia, Clinical Trials and Observations Source Type: research
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Source Type: research
Conclusion: The "Clo-Baltimore regimen" is safe and feasible and provides good survivals for patients with myeloid malignancies and haplo-donors. Methods: Here, we report a variant of the Baltimore regimen, where 1) fludarabine was replaced by clofarabine, 2) bone marrow was replaced by peripheral blood stem cells, and 3) tacrolimus was replaced by cyclosporine, in a "Clo-Baltimore regimen". PMID: 30323896 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Researchers have put together the largest dataset of acute myeloid leukemia, featuring 672 samples from 562 patients.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
More News: Acute Leukemia | Acute Myeloid Leukemia | Drugs & Pharmacology | Genetics | Leukemia