RNA-binding protein HuR inhibits the expression of sirtuin-1 in patients with COPD

Conclusions: Our results indicate that HuR expression is inhibited by oxidative stress, suggesting a potential mechanism by which SIRT1 is reduced in COPD patients, leading to the accelerated ageing phenotype.

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Baker, J. R., Vuppusetty, C., Ito, K., Barnes, P., Yasuo, K. Tags: Airway Cell Biology and Immunopathology Source Type: research