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Graph theoretical approaches towards understanding differences in frontoparietal and default mode networks in Autism.

Graph theoretical approaches towards understanding differences in frontoparietal and default mode networks in Autism. Proc IEEE Int Symp Biomed Imaging. 2017;2017:460-463 Authors: Riedel BC, Jahanshad N, Thompson PM Abstract Autism Spectrum Disorder is a complex developmental disorder affecting 1 in 68 children in the United States. While the prevalence may be on the rise, we currently lack a firm understanding of the etiology of the disease, and diagnosis is made purely on behavioral observation and informant report. As one method to improve our understanding of the disease, the current study took a systems-level approach by assessing the causal interactions among the frontoparietal and default mode networks using structural covariance of a large Autism dataset. Although preliminary, we report diffuse yet subtle changes throughout these networks when comparing age and sex matched controls to ASD patients. PMID: 29201281 [PubMed]
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research

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Many genes that increase the risk of autism spectrum disorders have been identified, but their mechanisms remain largely unknown. Now a team of UCLA researchers has received a five-year grant of more than $5 million from the National Institutes of Health to support its work to identify those mechanisms.Led by Dr. Daniel Geschwind at UCLA, researchers will work with counterparts at Stanford University to assess the specific impact of genetic mutations on alterations in molecular, cellular and neural circuitry. Geschwind is the Gordon and Virginia MacDonald Distinguished Chair in Human Genetics and a professor of neurology a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Publication date: March 2018 Source:Journal of Trace Elements in Medicine and Biology, Volume 46 Author(s): Matthew Mold, Dorcas Umar, Andrew King, Christopher Exley Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content ...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Condition:   Autism Spectrum Disorder Interventions:   Behavioral: SENSE Theatre;   Behavioral: Tackling Teenage Together Sponsor:   Vanderbilt University Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionFindings revealed ratings of anxiety in youth with and without autism spectrum disorder facing surgery varied by reporter and setting, highlighting the importance of using multiple reporters in research of youth with autism spectrum disorder in the perioperative period. Furthermore, while results showed group differences in premedication patterns and induction compliance, groups did not differ in level of negative behavior change after surgery. Future research can examine how individual differences in youth with autism impact anxiety in the perioperative setting and degree of behavior change postprocedure.
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: RESEARCH REPORT Source Type: research
Please note the NIH Neuroscience Series lecture on Monday, December 11, 2017 at noon in the Porter Neuroscience Research Center, Room 620, Building 35, has been cancelled due to bad weather and flight cancellation. NIH Neuroscience Series Seminar The brain is one of the most fascinating and complex systems in the body. It controls sensory perceptions, emotions, and actions and makes it possible to form memories and learn highly specialized behaviors. Changes in the connectivity and function of neurons underlie disorders such as autism and schizophrenia, which pose significant challenges to today's society. The aim of Dr. S...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
BACKGROUND: The reported prevalence of autism spectrum disorder (ASD) has increased markedly in the past two decades. Recent research indicates that children with ASD are at a substantially increased risk of injury mortality, particularly from unintentiona...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
This study is part of a larger systematic effort that will provide the basis to define ICF Core Sets for ASD, from which assessment tools can be generated for use in clinical practice, research, and health care policy making. Autism Res 2017. © 2017 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. Lay SummaryThe study findings support the need to understand the living experiences of individuals with Autism Spectrum Disorder (ASD) from a broader perspective, taking into account many areas of an individual's functioning and environment. The ICF can serve as f...
Source: Autism Research - Category: Psychiatry Authors: Tags: Research Article Source Type: research
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Source: Developmental Dynamics - Category: Molecular Biology Authors: Tags: Reviews Source Type: research
ABSTRACT Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia have an expansive array of reported genetic and environmental contributing factors. However, none of these factors alone can account for a substantial proportion of cases of either disorder. Instead, many gene‐by‐environment interactions are responsible for neurodevelopmental disturbances that lead to these disorders. The current experiment used heterozygous knock‐out mice to examine a potential interaction between two factors commonly linked to neurodevelopmental disorders and cognitive deficit: imbalanced excitatory/inhibitory...
Source: Genes, Brain and Behavior - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Data reveals just four in ten pregnant women have received the vaccine this year Related items fromOnMedica Flu during pregnancy not linked to child ’s autism risk Antenatal flu drugs not linked to newborn risks Last winter ’s flu vaccination ineffective for over 65s NHS winter plans centre on more flu jabs and A&E staff Parents urged to vaccinate children against flu
Source: OnMedica Latest News - Category: UK Health Source Type: news
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