Characterizing autoimmune disease-associated diffuse large B cell lymphoma in a SEER-Medicare cohort

We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to characterize patterns of presentation, treatment, and survival in older DLBCL patients with concomitant autoimmune disease. DLBCL patients with autoimmune disease were more likely to be female, but otherwise did not differ significantly from other DLBCL patients in demographics, treatments and clinical outcomes.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research

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IntroductionChronic graft-versus-host disease (cGVHD) affects up to 50% of the long-term survivors of allogeneic hematopoietic stem cell transplantation (HCT), and is the leading cause of mortality in patients who survive to two years post-transplant. Unlike acute GVHD (aGVHD), the primary pathology in cGVHD is fibrotic, affecting the skin, and lacrimal and salivary glands, and shares many features with the autoimmune conditions Sjogrens syndrome and systemic sclerosis. Certain gastrointestinal microbiota compositions have been associated with these autoimmune conditions, and we thus hypothesized that the configuration of ...
Source: Blood - Category: Hematology Authors: Tags: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: Biomarkers and the Microbiome Source Type: research
Publication date: Available online 5 September 2018Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Caroline M. Hsu, John M. Bennett, Brea LipeAbstractHemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory state characterized by phagocytosis of hematopoietic elements. It may be triggered by infection, malignancy, and autoimmune disorders and often progresses to multiorgan failure and even death.A 59-year-old man presented to our hospital for recurrent fevers in the setting of known IgA multiple myeloma complicated by end-stage renal disease requiring dialysis. Infectious workup was negative, and he was dia...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 5 September 2018Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Caroline M. Hsu, John M. Bennett, Brea LipeAbstractHemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory state characterized by phagocytosis of hematopoietic elements. It may be triggered by infection, malignancy, and autoimmune disorders and often progresses to multiorgan failure and even death.A 59-year-old man presented to our hospital for recurrent fevers in the setting of known IgA multiple myeloma complicated by end-stage renal disease requiring dialysis. Infectious workup was negative, and he was dia...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
There is a known association between Hodgkin lymphoma (HL) and autoimmune disorders with several case reports and case series describing diseases such as immune thrombocytopenia (ITP) in patients with HL, as well as population studies depicting a link between these phenomena. The following case report describes a patient initially presenting with ITP and subsequently being diagnosed with HL as well as primary biliary cirrhosis (PBC) and Hashimoto ’s thyroiditis. This case is unique as it is one of only a few case reports describing multiple autoimmune conditions in one patient with HL and in this scenario, the thromb...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
There is a known association between Hodgkin lymphoma (HL) and autoimmune disorders, with several case reports and case series describing diseases such as immune thrombocytopenia (ITP) in patients with HL, as well as population studies depicting a link between these phenomena. The following case report describes a patient initially presenting with ITP and subsequently diagnosed with HL as well as primary biliary cirrhosis (PBC) and Hashimoto thyroiditis. This case is one of only a few case reports describing multiple autoimmune conditions in a single patient with HL.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Authors: Bozda─č SC, Yüksel MK, Demirer T Abstract Stem cells can be either totipotent, pluripotent, multipotent or unipotent. Totipotent cells have the capability to produce all cell types of the developing organism, including both embryonic and extraembryonic tissues. The Hematopoietic Stem Cells (HSC) are the first defined adult stem cells (ASC) that give rise to all blood cells and immune system. Use of HSCs for treatment of hematologic malignancies, which is also called bone marrow (BM) transplantation or peripheral blood stem cells (PBSC) transplantation is the pioneer of cellular therapy and translation...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conclusion In the present retrospective claims-based cohort of older patients with DLBCL, concomitant AI disease was uncommon and was more likely to occur in female DLBCL patients, which likely reflects the greater incidence of AI disease in women. The possibility of lower LRS for SLE patients should be explored in future studies. Micro-Abstract We used the Surveillance, Epidemiology, and End Results (SEER)–Medicare-linked database to characterize the patterns of presentation, treatment, and survival in older diffuse large B-cell lymphoma (DLBCL) patients with concomitant autoimmune disease. DLBCL patients with autoi...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Conclusions In this retrospective claims-based cohort of older patients with DLBCL, concomitant AI disease was uncommon and was more likely to occur in female DLBCL patients, which likely reflects the higher incidence of AI disease in women. The possibility of lower LRS for SLE patients should be explored in future studies. Teaser We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to characterize patterns of presentation, treatment, and survival in older DLBCL patients with concomitant autoimmune disease. DLBCL patients with autoimmune disease were more likely to be female, but otherwis...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
We used the Surveillance, Epidemiology, and End Results (SEER) –Medicare-linked database to characterize the patterns of presentation, treatment, and survival in older diffuse large B-cell lymphoma (DLBCL) patients with concomitant autoimmune disease. DLBCL patients with autoimmune disease were more likely to be female but otherwise did not differ significant ly from other DLBCL patients in demographic data, treatment, or clinical outcomes.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoma frequently associated with monoclonal gammopathy and autoimmune disorders. Therefore, whereas it is well known that the prevalence of autoimmune hemolytic anemia (AIHA) is highest in the more advanced stages of the disease and may depend on the type of treatment administered.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
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