Insulin degludec overdose may lead to long ‐lasting hypoglycaemia through its markedly prolonged half‐life

ConclusionAlthough the reported half‐life of insulin degludec in the body is ~25 h when administered in standard doses (0.4–0.8 units/kg), no study has investigated its half‐life after overdose. In the present case, the half‐life of insulin degludec was ~1.6 times longer than that observed with standard doses, probably leading to long‐lasting hypoglycaemia. Physicians should be aware of the possibility of unexpected long‐lasting severe hypoglycaemia resulting from insulin degludec overdose.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - Category: Endocrinology Authors: Tags: Case Report Source Type: research