Rutin Scavenges Reactive Oxygen Species, Inactivates 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK) and Increases NIS expression in thyroid PCCL3 Cells.

CONCLUSIONS: The flavonoid rutin seems to be an important stimulator of radioiodide uptake, acting at multiple levels, an effect that can be due to decreased oxidative stress, reduced AMPK activation, or both. Since thyroid iodide uptake is crucial for effective radioiodine therapy, our results suggest that rutin could be useful as candidate for adjuvant in radioiodine therapy. PMID: 29160164 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research