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Ischemic lesions and superficial siderosis in CAA: Partners in crime or innocent bystanders?

Cerebral amyloid angiopathy (CAA), first described in 1927 as a congophilic angiopathy associated with amyloid plaque in brains of patients with Alzheimer dementia,1 has an association with large and small intracranial hemorrhages (ICH). The differential diagnosis of ICH therefore includes CAA, especially in older patients or those without hypertension. The widely used Boston Criteria for diagnosis of CAA in vivo rely on the hemorrhagic characteristics of the disease.2 The pathophysiology of ICH in CAA remains uncertain. Thus, its prognosis, risk stratification, and clinical management present a challenge. Additional imaging features of CAA have contributed potential new perspectives on pathophysiology. The report of ischemic lesions in CAA may represent a novel concept for most clinicians accustomed to thinking about CAA as a hemorrhagic disease. The observation that Alzheimer dementia brains with severe amyloid angiopathy had more prevalent infarcts3–5 prompted subsequent investigations suggesting that amyloid deposition in small and medium-sized cortical vessels may play an active role in ischemia through pathologic thickening of the vessel wall, producing reduction or obliteration of the vessel lumen.6,7 Cortical superficial siderosis (cSS), easy to detect with modern MRI, is a striking and common feature of CAA. How these additional imaging features fit into a larger model of CAA remains unclear. Are they an epiphenomenon or can they teach us about the disease? In ...
Source: Neurology - Category: Neurology Authors: Tags: EDITORIALS Source Type: research

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Recent studies have identified biomarkers which can help predict the risk, as well as recognize the existence, of Alzheimer’s disease. Now, researchers involved with the National Institute on Aging (NIA) and the Alzheimer’s Association (AA) have proposed a new biomarker-based definition of Alzheimer’s disease. An article published in the April 2018 journal Alzheimer’s &Dementia discusses the proposal that Alzheimer’s disease should be defined by measurable, underlying pathologic processes that are able to be documented by either biomarkers or autopsy. This definition would be used for obse...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Memory and Perception Mental Health and Wellness Research Alzheimer's disease Biomarker Clinical Trials Dementia Genetics Memory Loss Source Type: blogs
This studycounters that notion, and the findings may suggest that many senior citizens remain more cognitively and emotionally intact than commonly believed. "We found that older people have similar ability to make thousands of hippocampal new neurons from progenitor cells as younger people do. We also found equivalent volumes of the hippocampus (a brain structure used for emotion and cognition) across ages. Nevertheless, older individuals had less vascularization and maybe less ability of new neurons to make connections. It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive fun...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractPurpose of ReviewConcepts of pulsatile arterial haemodynamics, including relationships between oscillatory blood pressure and flow in systemic arteries, arterial stiffness and wave propagation phenomena have provided basic understanding of underlying haemodynamic mechanisms associated with elevated arterial blood pressure as a major factor of cardiovascular risk, particularly the deleterious effects of isolated systolic hypertension in the elderly. This topical review assesses the effects of pulsatility of blood pressure and flow in the systemic arteries on the brain. The review builds on the emerging notion of the...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
CONCLUSIONS: In this large, diverse cohort, multiple measures of PPF in early adulthood to midlife were associated with dementia risk independent of smoking and vascular comorbidities. PMID: 29543604 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Publication date: Available online 16 March 2018 Source:Pharmacological Research Author(s): Francesca Pistollato, Ruben Calderón Iglesias, Roberto Ruiz, Silvia Aparicio, Jorge Crespo, Luis Dzul Lopez, Piera Pia Manna, Francesca Giampieri, Maurizio Battino Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer’s disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions se...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Women with high physical fitness at middle age were nearly 90 percent less likely to develop dementia according to a new study.byAlzheimer's Reading RoomThe information in this study is significant.An important finding of the study is thatwhen highly fit women did develop dementia, they developed the disease an average of 11 years later than women who were moderately fit, or at age 90 instead of age 79.Previous studies indicate that if the onset of Alzheimer's could be delayed to the age of 90,the number of people living with dementia would be cut in half.Currently,at age 80 there is a thirty percent of being diagnosed wit...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer care alzheimers alzheimers research alzheimers statistics care of dementia patients dementia care exercise fitness women Source Type: blogs
Men and women follow the Wheat Belly lifestyle and can undergo important and sometime startling hormonal changes. Though results vary with stage of life—young adults, middle-aged, older—there are a variety of hormonal changes that women and men typically experience, some in concert, others independently. Such hormonal shifts can be powerful and part of the health-restoring menu of changes that develop with this lifestyle. They can even improve a relationship in a number of ways, both physically and emotionally, especially if we weave in some of the newer Wheat Belly/Undoctored concepts and practices such as oxy...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle estradiol estrogen hormonal hormones Inflammation low-carb oxytocin testosterone Thyroid Weight Loss Source Type: blogs
Conclusions: We explore the currently available evidence about the hypertensive vasculopathy and inflammatory changes that occur in CSVD. Both are vital prognostic indicators of the development of cognitive impairment. Future studies should be performed to validate the relationship between BP levels and CSVD progression and between the numbers, volumes, and anatomical locations of CSVD and cognitive impairment. PMID: 29483399 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
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